The role of kinases on multiple G proteins activation by endothelin A receptor

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G protein coupled receptors, like as endothelin A receptor, are the transmembrane spanning receptors, and the most commonly targeted receptor class for medicinal therapeutics. Agonist binding to the receptor causes them to adopt a conformation that results in the activations of associated multiple heterotrimeric G proteins, but it is still unknown how to selective activated the various G proteins by single receptor. It was clarified the role of protein kinases and lipid rafts on the selective activation of multiple G proteins mediated by receptor.