Synthesis the naphto[1,8-bc]furan and polycyclic heterocycles with good bioactivity.

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Polycyclic heterocycles were known as the privileged compound, and their structural features were consisted rigid conforamation and were highly-reactive to the biomolecules. It was extremely difficult for the synthesis of the compounds because of their high-reactivity. Particularly, the naphto[1,8-bc]furan ring system was consisted a lot of enzyme inhibitors, such as wortomanin, halenaquinone and xestoquinone. A convinced synthetic route for the core ring system was developed by tandem [4+2] cycloaddition/aromatization sequence of allenyl 2-halo-3-vinylcyclohex-2-enyl ethers. Furthermore, the antiproliferative activity by the polycyclic heterocycles was identified.