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Mechanisms of KCNQ1 channel modulation by KCNE proteins revealed by ascidian KCNQ1 homologue

Mechanisms of KCNQ1 channel modulation by KCNE proteins revealed by ascidian KCNQ1 homologue
海鞘 KCNQ1 同源物揭示 KCNE 蛋白调节 KCNQ1 通道的机制
批准号:
20790184
负责人:
NAKAJO Koichi
金额:
$2.75万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009

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中文摘要
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英文摘要
KCNQ1, a voltage-gated potassium channel main subunit, is expressed in various tissues like heart, inner ear and intestine, and also known as a causative gene for cardiac arrhythmia and deafness. The property of this ion channel is largely dependent on its auxiliary subunit, KCNE proteins. In this study, we identified some important amino acid residues for KCNQ1 channel modulation by KCNE proteins by comparing human KCNQ1 gene to KCNQ1 homologue from ascidian Ciona intestinalis
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Stoichiometry of KCNQ1-KCNE1 ion channel complex is flexible and density dependent
KCNQ1-KCNE1 离子通道复合物的化学计量是灵活且依赖于密度的
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Koichi Nakajo, Maximilian Ulbrich, Yoshihiro Kubo, Ehud Isacoff]
通讯作者: Ehud Isacoff
DOI: 10.1113/jphysiol.2007.148601
发表时间: 2008-06-15
期刊: JOURNAL OF PHYSIOLOGY-LONDON
影响因子: 5.5
作者: [Nakajo, Koichi, Kubo, Yoshihiro]
通讯作者: Kubo, Yoshihiro
Identification and characterization of Cs+-permeable K+ channel current in mouse cerebellar Purkinje cells in lobules 9 and 10 evoked by molecular layer stimulation
分子层刺激引起的小鼠小脑小叶 9 和 10 浦肯野细胞中 Cs 渗透性 K 通道电流的鉴定和表征
DOI: --
发表时间: 2010
期刊: Eur J Neurosci (in press)
影响因子: --
作者: [Ishii H, Nakajo K, Yanagawa Y, Kubo Y.]
通讯作者: Kubo Y.
DOI: 10.1085/jgp.200810002
发表时间: 2009-01
期刊: The Journal of general physiology
影响因子: --
作者: [Fujiwara Y, Keceli B, Nakajo K, Kubo Y]
通讯作者: Kubo Y
12
    Functional analysis of auxiliary subunits of KCNQ1 channels in the heart
    Stoichiometry and current kinetics of KCNQ1-KCNE1 ion channel complex
    Detection of state-dependent change of the stoichiometry of KCNQ1-KCNE1 complex by single molecule imaging
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