Characterization of the cellular oxygen sensing machinery

生物体对低氧条件的反应是通过调节呼吸和新陈代谢来维持动态平衡。目前还不清楚体内的“氧气传感器”分子是什么。在本研究中，我们对由Pro-羟基酶PHD3形成的缺氧复合体进行了表征。结果，我们确定了几种不同的分子，它们将在氧气传感中发挥作用。PDH调节细胞的代谢，而PRP19则抑制缺氧细胞的死亡。

Organisms respond to hypoxia condition by regulating respiration and metabolism to maintain homeostasis. It is not clear yet what is the 'oxygen sensor' molecule in vivo. In the present study, we have characterized the hypoxia complex which is formed by prolyl-hydroxylase PHD3. As a result, we identified several different molecules which would play roles in oxygen sensing. PDH regulated the metabolism, while PRP19 suppressed the cell death in hypoxia treated cells.