Genomic profiling of gastric carcinoma in situ by array-based comparative genomic hybridization

通过基于阵列的比较基因组杂交对胃癌进行原位基因组分析

• 批准号: 20790286
• 负责人: TSUKAMOTO Yoshiyuki
• 金额: $ 2.66万
• 依托单位: Oita University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790286/
• 关键词: 分子病理; アレイCGH; 早期胃癌; 胃腺腫; ゲノムコピー数異常; 進行胃癌

Although genomic copy number aberrations (CNAs) of gastric carcinoma at the advanced stage have already been extensively characterized by array comparative genomic hybridization (array CGH) analysis, those of gastric carcinoma in situ (CIS) are still poorly understood. In this study, we investigated CNAs of 20 gastric CISs (Vienna category 4.2) using oligonucleotide-based array CGH. The most frequent aberrations in CIS were gains at 8q (85%) and 20q (50%), and losses at 5q (50%) and 17p (50%), suggesting that these CNAs are involved in the development of CIS.

尽管阵列比较基因组杂交技术已广泛应用于进展期胃癌的基因组拷贝数异常分析，但对胃癌原位癌的基因组拷贝数异常仍知之甚少。在这项研究中，我们使用基于寡核苷酸的阵列CGH研究了20个胃CI(维也纳4.2类)的CNAs。在CIS中最常见的异常是8q(85%)和20q(50%)的增加，5q(50%)和17p(50%)的丢失，这表明这些CNA参与了CIS的发展。

项目成果

Genomic profiling of gastric carcinoma in situ and adenomas by array-based comparative genomic hybridization

• DOI: 10.1002/path.2686
• 发表时间: 2010-05-01
• 期刊: JOURNAL OF PATHOLOGY
• 影响因子: 7.3
• 作者: Uchida, Masahiro;Tsukamoto, Yoshiyuki;Moriyama, Masatsugu
• 通讯作者: Moriyama, Masatsugu

MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zeta.

MicroRNA-375 在胃癌中下调，并通过靶向 PDK1 和 14-3-3zeta 来调节细胞存活。

• 发表时间: 2010
• 期刊: Cancer Res. 70
• 作者: Tsukamoto;Y
• 通讯作者: Y

Genome-wide microRNA expression profiling in gastric carcinoma

胃癌全基因组 microRNA 表达谱

• 发表时间: 2009
• 作者: Nakada;et.al.;塚本善之
• 通讯作者: 塚本善之

Genome-wide analysis of DNA copy number alterations and gene expression in gastric cancer

• DOI: 10.1002/path.2424
• 发表时间: 2008-12-01
• 期刊: JOURNAL OF PATHOLOGY
• 影响因子: 7.3
• 作者: Tsukamoto, Y.;Uchida, T.;Moriyama, M.
• 通讯作者: Moriyama, M.

Genome-wide microRNA expression profiling in renal cell carcinoma: significant down-regulation of miR-141 and miR-200c

• DOI: 10.1002/path.2437
• 发表时间: 2008-12-01
• 期刊: JOURNAL OF PATHOLOGY
• 影响因子: 7.3
• 作者: Nakada, C.;Matsuura, K.;Moriyama, M.
• 通讯作者: Moriyama, M.