Development of a logistic regression predictive model for the outcome of patients with resected lung adenocarcinoma of 2cm or less in size

开发2cm或更小肺腺癌切除患者预后的逻辑回归预测模型

• 批准号: 20790294
• 负责人: SAKUMA Yuji
• 金额: $ 2.83万
• 依托单位: Kanagawa Cancer Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20790294/
• 关键词: 小型肺腺癌; 術後再発; アポトーシス; 予後予測式; 脈管浸潤

本研究では、最大径2cm以下の小型肺腺癌の術後再発を概ね正確に予想するため判別式を作製することができた。さらに術後再発を規定する最大の因子は脈管浸潤の有無であったため、脈管内に浸潤した肺腺癌細胞をアポトーシス(細胞死)させるための研究も併せて行い、Srcの活性化が肺腺癌のアポトーシス抵抗性に関与していることを示すことができた。

In this study, the diagnosis of small lung adenocarcinoma below the maximum diameter of 2cm is correct. After treatment, it was specified that the largest factor was immersed in the tube, the lung adenocarcinoma cell was immersed in the tube, the lung adenocarcinoma cell died, the lung adenocarcinoma was activated by Src, the lung adenocarcinoma was activated, the lung adenocarcinoma was activated, and the lung adenocarcinoma was activated.

项目成果

A logistic regression predictive model and the outcome of patients with resected lung adenocarcinoma of 2 cm or less in size.

逻辑回归预测模型和切除大小为 2 厘米或更小的肺腺癌患者的结果。

• DOI: 10.1016/j.lungcan.2008.10.011
• 发表时间: 2009
• 期刊: Lung cancer
• 影响因子: 5.3
• 作者: Y. Sakuma;N. Okamoto;H. Saito;Kouzo Yamada;T. Yokose;M. Kiyoshima;Y. Asato;R. Amemiya;Hitoaki Saitoh;S. Matsukuma;M. Yoshihara;Yoshiyasu Nakamura;F. Oshita;H. Ito;H. Nakayama;Y. Kameda;E. Tsuchiya;Y. Miyagi
• 通讯作者: Y. Miyagi

Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing Src

漂浮在淋巴管中的肺腺癌细胞通过表达Src来抵抗失巢凋亡

• 发表时间: 2009
• 作者: Sakuma Y;et al.
• 通讯作者: et al.

予後不良の小型肺腺癌の特徴を明らかにするための研究

阐明预后不良的小肺腺癌特征的研究

• 发表时间: 2008
• 作者: 佐久間裕司;中村圭靖;亀田陽一;横瀬智之;土屋永寿;宮城洋平
• 通讯作者: 宮城洋平

Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated

漂浮在淋巴管中的肺腺癌细胞通过表达磷酸化来抵抗失巢凋亡

• 发表时间: 2010
• 期刊: J Pathol 220
• 作者: Sakuma Y;Takeuchi T;Nakamura Y;Yoshihara M;Matsukuma S;Nakayama H;Ohgane N;Yokose T;Kameda Y;Tsuchiya E;Miyagi Y.
• 通讯作者: Miyagi Y.

Lung adenocarcinoma cells floating in lymphatic vessels resist anoikis by expressing phosphorylated Src

• DOI: 10.1002/path.2676
• 发表时间: 2010-04-01
• 期刊: JOURNAL OF PATHOLOGY
• 影响因子: 7.3
• 作者: Sakuma, Yuji;Takeuchi, Tomoyo;Miyagi, Yohei
• 通讯作者: Miyagi, Yohei