Research of the mechanism that occludin regulate microvilli formation and fence function in epithelial cells

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Expression of occludin induces microvilli formation in epithelial cells. But there is no change in the expression of the molecules associated with microvilli (ezrin, radixin, moesin, and EBP-50) at protein and mRNA level. Occludin regulates the localization of ezrin by controlling the phosphorylation of ezrin in this time. In addition, a similar change is seen when introducing only C-terminal cytoplasmic domain of occludin is transfected in non-epithelial cells. Occludin may play an important role in the formation of microvilli in epithelial cells by phosphorylation of molecules associated with microvilli via the C-terminal cytoplasmic domain.