Analysis of nuclear export of influenza viral RNP and search for novel inhibitors using the mechanisms

抗病毒药物用于流感，但已有抗药性病毒的报道。我主要关注流感病毒RNP复合体的核出口过程，因为这些过程对于新型抗流感病毒药物的开发是重要的。本研究对vRNP的核输出机制进行了分析，并对新型流感病毒药物进行了筛选。从海洋细菌库中发现了几个候选菌株，进一步的纯化和鉴定正在进行中。

Antivirals are used for influenza, however resistant viruses have been reported. I focus on the nuclear export processes of influenza viral RNP complex because the processes are important for the development of novel anti-influenza viral drugs. In this study, analysis of the mechanisms for the nuclear export of vRNP, and screening of novel influenza viral drugs were performed. Several candidates from marine bacteria library are found, and further purification and identification are in progress.