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Functional compensation and independency of two sphingomyelin synthases

Functional compensation and independency of two sphingomyelin synthases
两种鞘磷脂合酶的功能补偿和独立性
批准号:
20570145
负责人:
WATANABE Ken
金额:
$3.08万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
Two sphingomyelin synthase, SMS1 and SMS2, are structurally homologous proteins but exhibit different cellular localization. In this study, mice deficient either for Sms1 or Sms2 gene were generated. Through the phenotypic analyses of Sms1KO and Sms2KO mice, the enzymes partially compensate in sphingomyelin biosynthesis but play different roles in biological aspects and physiology.
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DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [光武進, 横田はづき, 座間宏太, 山下匡, 岡崎俊朗, 渡辺研, 五十嵐靖之]
通讯作者: 五十嵐靖之
骨芽細胞の分化と骨形成
成骨细胞分化和骨形成
DOI: --
发表时间: 2009
期刊: 日本臨床 67
影响因子: --
作者: [渡辺研, 池田恭治]
通讯作者: 池田恭治
細胞内スフィンゴミエリン量の細胞増殖及び糖脂質合成に与える影響
细胞内鞘磷脂含量对细胞增殖和糖脂合成的影响
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [座間宏太, 林遥, 光武進, 角南寛, 山下匡, 渡辺研, 岡崎俊郎, 五十嵐靖之]
通讯作者: 五十嵐靖之
DOI: 10.1007/s12018-010-9076-0
发表时间: 2010-11
期刊: Clinical Reviews in Bone and Mineral Metabolism
影响因子: 1.8
作者: [Ken Watanabe;K. Ikeda]
通讯作者: Ken Watanabe;K. Ikeda
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