Elucidation of function of tra2 beta alternative splicing mRNA isoform

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In this study, we focused on a RNA-binding protein, Tra2b, that regulates alternative splicing. We observed that tra2b itself transiently induced its alternative splicing isoform, tra2b4, by stress stimuli. This induction was not involved in the self-regulation of expression level of tra2b. Different mechanisms seem to exist. Furthermore, we confirmed that Tra2b were involved in the alternative splicing regulation of CD44 by oxidative stress. CD44 is known to be a cancer cell surface marker and have been suggested to participate in tumor progression and metastasis. We published these results on a scientific journal.