Self-monitoring dysfunction in schizophrenia using event related potential studies

本研究采用事件相关电位研究精神分裂症患者的自我监控功能障碍。采用听觉失配负性任务，受试者包括精神分裂症患者和正常对照组。与正常对照组相比，首发精神分裂症患者的事件相关电位波幅相对较低，但组间差异无显着性。慢性精神分裂症患者MMN降低，提示MMN可作为反映精神分裂症进行性变化的生物标志物之一。我们还在继续进行进一步的研究，包括纵向研究和脑内记录EEG研究。

Self monitoring dysfunction in schizophrenia was investigated in this study using event related potentials. The auditory mismatch negativity task was employed and subjects including both patients with schizophrenia and normal controls were participated in this study. The grand mean event related potential waves showed relatively reduced in first episode schizophrenia compared with normal controls but there is no significant difference between groups. Patients with chronic schizophrenia showed reduced MMN and that would suggest that MMN could be one of the biological markers to reflect the progressive change in schizophrenia. We still continue further studies including the longitudinal studies and intra-cranial recording EEG studis.