Development and evaluation of a novel PET probe for EGFR

为量身定制的药物创造新的诊断和治疗产品至关重要。在这项研究中，我们开发了针对激活的EGFR的新型分子探针，它被认为参与了癌症的发生和肿瘤的恶性。探针在细胞中的滞留与EGFR的激活有关，而组织中的摄取模式取决于EGFR的量/激活。此外，连续注射探针可显著抑制肿瘤生长。本研究将有助于癌症诊断和癌症治疗的发展。

It is of key importance to create novel diagnostic and treatment products for tailor-made medicine. In this study, we developed novel molecular probes targeting activated-EGFR which is known to be involved in carcinogenesis and tumor malignancy. Probe retention in cells was correlated with EGFR activation, and the uptake pattern into tissues was dependent on EGFR amount/activation. In addition, tumor growth was dramatically suppressed with consecutive probe injection. This study could help the development of cancer diagnosis and cancer therapy.