Autologous rabbit bone marrow-derived cells implanted into radiation-injured urinary bladders recovery functional tissue structures

自体兔骨髓来源细胞植入辐射损伤膀胱恢复功能组织结构

• 批准号: 20791104
• 负责人: IMAMURA Tetsuya
• 金额: $ 2.66万
• 依托单位: Shinshu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791104/
• 关键词: 再生医療; 膀胱組織再生; 放射線照射傷害; 自己骨髄由来細胞移植; フラッシュアウト法; 細胞培養; 自己細胞移植; 骨髄細胞; 放射線傷害; 膀胱; 膀胱内圧; ウサギ

We investigated to determine if implantation of autologous bone marrow-derived cells into radiation-injured urinary bladders recovered functional tissue structures. In this study, we attempted to produce the radiation-injured urinary bladders, however the proper models were not established. We have established the methods to obtain high quality autologous bone marrow-derived cells. Therefore, our projects had been developed.

我们进行了研究，以确定将自体骨髓来源的细胞植入辐射损伤的膀胱中是否可以恢复功能性组织结构。在这项研究中，我们尝试制作辐射损伤的膀胱，但尚未建立合适的模型。我们已经建立了获得高质量自体骨髓来源细胞的方法。因此，我们的项目已经开发出来。

项目成果

Implanted mouse bone marrow-derived cells reconstruct layered smooth muscle structures in injured urinary bladders

• DOI: 10.3727/096368908784153850
• 发表时间: 2008-01-01
• 期刊: CELL TRANSPLANTATION
• 影响因子: 3.3
• 作者: Imamura, Tetsuya;Kinebuchi, Yoshiaki;Nishizawa, Osamu
• 通讯作者: Nishizawa, Osamu

The Microenvironment of Freeze-injured Mouse Urinary Bladders Enables Successful Tissue Engineering.

冻伤小鼠膀胱的微环境使组织工程成功成为可能。

• 发表时间: 2009
• 期刊: Tissue Engineering 15(11)
• 作者: Tetsuya Imamura;Tomonori Yamamoto;(他3名)
• 通讯作者: (他3名)

Mice Freeze-injured Urinary Bladders Provide a Microenvironment for Bone Marrow-Derived Cells to Regenerate Smooth Muscle Layers

小鼠冷冻损伤的膀胱为骨髓源性细胞再生平滑肌层提供微环境

• 发表时间: 2009
• 作者: Tetsuya Imamura;Osamu Ishizuka;(他6名);今村哲也;今村哲也;今村哲也
• 通讯作者: 今村哲也

Stimulation of Skin Menthol Receptors Stimulates Detrusor Activity in Conscious Rats

刺激皮肤薄荷醇受体可刺激清醒大鼠的逼尿肌活动

• DOI: 10.1002/nau.20774
• 发表时间: 2010
• 期刊: Neurourology and Urodynamics
• 影响因子: 2
• 作者: 陳忠;石塚修;今村哲也
• 通讯作者: 今村哲也

Gosha-jinki-gan Reduces Transmitter Protein and Sensory Receptors Associated with C Fiber Activation Induced by Acetic Acid in Rat Urinary Bladder.

Gosha-jinki-gan 减少大鼠膀胱中与乙酸诱导的 C 纤维活化相关的递质蛋白和感觉受体。

• 发表时间: 2008
• 期刊: Neurourology and Urodynamics 27
• 作者: Tetsuya Imamura;Osamu Ishizuka;(他6名)
• 通讯作者: (他6名)