The mechanism of water absorption in the endolymphatic sac
The mechanism of water absorption in the endolymphatic sac
批准号:
20791179
负责人:
NAKAYA Kazuhiro
金额:
$2.41万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2009
中文摘要
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英文摘要
AQP2 mRNA was knocked down by placing siRNA specific to rat AQP2 at the round window membrane. The samples were harvested 48 hours after the intervention. The immunohistochemical study under the fluorescent microscope revealed that the expression of the AQP2 in the endolymphatic sac was reduced in the group treated with AQP2 siRNA compared to the group treated with negative control siRNA. Neither endolymphatic hydrops nor endolymphatic collapse occurred in both groups.
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依托单位:
海外基金