Bral2 is essential for the maintenance of the extracellular microenvironment for the synaptic transmission in the auditory system.

大脑中有两种类型的细胞：神经细胞和胶质细胞。细胞外基质(ECM)存在于这些细胞的胞外区，如透明质酸和蛋白多糖。脑内有两个密集的有组织的细胞外基质，一个在周围神经网络(PNN)中，另一个在Ranvier结点。PNN是围绕神经细胞的网状结构。Bral2与透明质酸和蛋白多糖形成细胞外基质复合体，定位于听觉系统的PNN。在这项研究中，通过对Bral缺陷小鼠的分析，强烈地表明Brals在ECM组装中起关键作用，并且该复合体对神经元活动是必不可少的

There are two types of cells in the brain ; the neuronal cell and glial cell. Extracellular matrix (ECM), such as hyaluronan and proteoglycan, exists in extracellular region of these cells. There are two dense organized ECM in the brain, one is in the perineuronal net (PNN) and other is at the node of Ranvier. The PNN is a mesh like structure surrounding the neuronal cell. Bral2 forms ECM complex with hyaluronan and proteoglycan, and is localized in the PNN of the auditory system. In this study, it is strongly suggested that Brals play key roles in the ECM assembly and the complex is essential for the neuronal activity through the analysis of Bral - deficient mice