A relationship between epithelial sodium absorption and eosinophilic inflammation

上皮细胞钠吸收与嗜酸性粒细胞炎症的关系

• 批准号: 20791214
• 负责人: YASUDA Makoto
• 金额: $ 2.08万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791214/
• 关键词: 好酸球性炎症; イオン輸送; 培養細胞; 培養上皮細胞

The mechanism of cytokine secretion by IL-4 was investigated in cultured a human nasal polyp epithelial cells. The most secreted cytokine was RANTS, but eotaxin was not detected in our studies. Treatment of 100ng/ml IL-4 significantly increased RANTES secretion, and this activation was observed at 72 hours after treatment.

在体外培养的人鼻息肉上皮细胞中，研究了IL-4分泌细胞因子的机制。分泌最多的细胞因子是RANTS，但在我们的研究中没有检测到嗜酸性粒细胞趋化因子。100 ng/mlIL-4处理可显著增加RANTES的分泌，并在处理后72小时出现这种激活。