The effect of nicaraven to organ dysfunctions in sepsis

尼卡拉文对脓毒症器官功能障碍的影响

• 批准号: 20791326
• 负责人: SUZUKI Takeshi
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20791326/
• 关键词: 敗血症; 臓器障害; 活性酸素種; ニカラベン; 臓器保護; 心筋保護

I examined the effects of nicaraven to sepsis, using a rat cecal ligation and perforation model. At first, I evaluated whether a nicaraven infusion has beneficial effects to mortality and cardiac dysfunction or not. In the evaluation of cardiac function, I measured cardiac output, cardiac work and cardiac efficiency using a working heart model. Although there are only a few datas, a nicaraven therapy has little beneficial effects to mortality and cardac dysfunction at this time.

我用大鼠盲肠结扎穿孔模型检验了尼卡拉文对败血症的影响。首先，我评估了输注尼卡拉文是否对死亡率和心功能障碍有有益的影响。在心功能评估中，我使用工作心脏模型测量了心输出量、心功和心效率。虽然只有很少的数据，但尼加拉瓜文治疗目前对死亡率和心脏功能障碍几乎没有有益的影响。