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Functional characterization of candidate disease genes identified by the efficient insertional mutagenesis

Functional characterization of candidate disease genes identified by the efficient insertional mutagenesis
通过有效插入诱变鉴定的候选疾病基因的功能表征
批准号:
21590303
负责人:
SUZUKI Takeshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011

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中文摘要
翻译
小鼠逆转录病毒插入突变是高通量筛选肿瘤基因的重要策略之一。利用该系统,我们已经鉴定出了大部分组蛋白赖氨酸甲基转移酶基因和脱甲基酶基因作为候选癌基因或抑癌基因。我们已经发现,一些酶不仅参与肿瘤的发生,而且参与恶性肿瘤的进展,如细胞侵袭
英文摘要
Retroviral insertional mutagenesis in mice is one of the important strategies for high-throughput identification of cancer genes. Using this system, we have so far identified most of histone lysine methyltransferase genes and demethylase genes as candidate oncogenes or tumor suppressor genes. We have found that some of the enzymes are involved not only in the tumor initiation but also in the malignant tumor progression such as cell invasion
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会议论文
Jmjd5, which is identified by retroviral insertional mutagenesis, regulates Cdknla and modulates embryonic cell growth
Jmjd5 通过逆转录病毒插入突变鉴定,可调节 Cdknla 并调节胚胎细胞生长
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ishimura A, Terashima M, Suzuki T.]
通讯作者: Suzuki T.
Jmjd5, which is identified by retroviral insertional mutagenesis, regulates Cdkn1a and modulates embryonic cell growth
Jmjd5 通过逆转录病毒插入突变鉴定,可调节 Cdkn1a 并调节胚胎细胞生长
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Ishimura A, Terashima M, Suzuki T]
通讯作者: Suzuki T
Functional characterization of JmjC domain-containing proteins and SET domain-containing proteins involved in cancer
涉及癌症的含 JmjC 结构域蛋白和含 SET 结构域蛋白的功能表征
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Terashima M, Ishimura A, Yoshida M, Suzuki T.]
通讯作者: Suzuki T.
Involvement of histone methyltransferases and demethylases in mouse retrovirus-induced leukemia/lymphoma
组蛋白甲基转移酶和去甲基酶参与小鼠逆转录病毒诱导的白血病/淋巴瘤
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Kamei, J, Suzuki T.]
通讯作者: Suzuki T.
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