Functional characterization of candidate disease genes identified by the efficient insertional mutagenesis
Functional characterization of candidate disease genes identified by the efficient insertional mutagenesis
批准号:
21590303
负责人:
SUZUKI Takeshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2009
资助国家:
日本
项目状态:
已结题
起止时间:
2009 至 2011
中文摘要
小鼠逆转录病毒插入突变是高通量筛选肿瘤基因的重要策略之一。利用该系统,我们已经鉴定出了大部分组蛋白赖氨酸甲基转移酶基因和脱甲基酶基因作为候选癌基因或抑癌基因。我们已经发现,一些酶不仅参与肿瘤的发生,而且参与恶性肿瘤的进展,如细胞侵袭
英文摘要
Retroviral insertional mutagenesis in mice is one of the important strategies for high-throughput identification of cancer genes. Using this system, we have so far identified most of histone lysine methyltransferase genes and demethylase genes as candidate oncogenes or tumor suppressor genes. We have found that some of the enzymes are involved not only in the tumor initiation but also in the malignant tumor progression such as cell invasion
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Jmjd5, which is identified by retroviral insertional mutagenesis, regulates Cdknla and modulates embryonic cell growth
Jmjd5 通过逆转录病毒插入突变鉴定,可调节 Cdknla 并调节胚胎细胞生长
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ishimura A, Terashima M, Suzuki T.]
通讯作者:
Suzuki T.
Jmjd5, which is identified by retroviral insertional mutagenesis, regulates Cdkn1a and modulates embryonic cell growth
Jmjd5 通过逆转录病毒插入突变鉴定,可调节 Cdkn1a 并调节胚胎细胞生长
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Ishimura A, Terashima M, Suzuki T]
通讯作者:
Suzuki T
Functional characterization of JmjC domain-containing proteins and SET domain-containing proteins involved in cancer
涉及癌症的含 JmjC 结构域蛋白和含 SET 结构域蛋白的功能表征
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[Terashima M, Ishimura A, Yoshida M, Suzuki T.]
通讯作者:
Suzuki T.
Involvement of histone methyltransferases and demethylases in mouse retrovirus-induced leukemia/lymphoma
组蛋白甲基转移酶和去甲基酶参与小鼠逆转录病毒诱导的白血病/淋巴瘤
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Kamei, J, Suzuki T.]
通讯作者:
Suzuki T.
DOI:
10.1016/j.bbrc.2009.08.155
发表时间:
2009-11-13
期刊:
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
影响因子:
3.1
作者:
[Ishimura, Akihiko, Terashima, Minoru, Suzuki, Takeshi]
通讯作者:
Suzuki, Takeshi
共 26 条
RNAi-based pesticides against the hard-to-control spider mite, Tetranychus urticae
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批准号:18H02203
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项目类别:Grant-in-Aid for Scientific Research (B)
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财政年份:2018
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Study of the neutrino-flux via bound state beta-decay of bare 205Tl ions
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Therapeutic strategy for maintenance of lymphocyte function to improve the prognosis of sepsis
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财政年份:2017
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Study on Micro-Library as Town Resources
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批准号:15K14093
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.66万
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财政年份:2015
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负责人:SUZUKI Takeshi
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Neutron skin of Ni isotopes
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批准号:24244024
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$20.38万
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财政年份:2012
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负责人:SUZUKI Takeshi
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English Communication Programs for Enhancing Japanese Students' Advocacy Skills
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批准号:23520762
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.08万
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财政年份:2011
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Study on the glutamate-induced spinal neurodysfunction.
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批准号:23590113
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项目类别:Grant-in-Aid for Scientific Research (C)
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财政年份:2011
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负责人:SUZUKI Takeshi
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依托单位:
On representation theory from the view point of integrable systems
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批准号:22540048
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项目类别:Grant-in-Aid for Scientific Research (C)
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财政年份:2010
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The effect of nicaraven to organ dysfunctions in sepsis
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批准号:20791326
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财政年份:2008
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Epidemiological study between HPV infection and risk of head and neck cancer
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批准号:20790435
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.66万
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财政年份:2008
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负责人:SUZUKI Takeshi
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English Communication Education as Advocacy Training:
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批准号:19520511
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资助金额:$1.83万
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财政年份:2007
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负责人:SUZUKI Takeshi
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依托单位:
Functional characterization of candidate disease genes identified by the efficient bi-allelic insertional mutagenesis
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批准号:19590274
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.91万
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财政年份:2007
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负责人:SUZUKI Takeshi
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依托单位:
Study of the EC and bound state β decay and its half-life on the highly charged ions.
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财政年份:2007
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依托单位:
Algebras related to integrable systems
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批准号:18740009
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项目类别:Grant-in-Aid for Young Scientists (B)
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财政年份:2006
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负责人:SUZUKI Takeshi
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Study of AMPA receptor dysfunctions in CNS diseases
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批准号:18590239
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负责人:SUZUKI Takeshi
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Nuclear radii measurment of Kr isotopes with the fragment separator
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批准号:16340063
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.74万
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财政年份:2004
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负责人:SUZUKI Takeshi
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依托单位:
English Debate Program as Cross-Cultural Communication Training
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批准号:15520370
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$0.9万
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财政年份:2003
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负责人:SUZUKI Takeshi
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依托单位:
Neutron Halo Structure in exiotic nuclei (^<17>B,^<22>N,^<23>O etc.)
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批准号:13440075
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.34万
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财政年份:2001
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负责人:SUZUKI Takeshi
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Fc receptor signal initiation mechanisms at lipid rafts
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批准号:13670451
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2001
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负责人:SUZUKI Takeshi
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Environmental Design from the View Point of "IKATA"
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负责人:SUZUKI Takeshi
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依托单位:
海外基金