The anti-inflammatory effect of irsogladine maleate in human gingival tissue.

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By regulating the intercellular junctional complex and chemokine secretion in human gingival epithelial cells (HGEC), irsogladine maleate (IM) may be useful to prevent periodontal disease. To clarify the effects and regulatory mechanism of IM in vivo and in vitro, we examined the expression of E-cadherin and neutrophil chemotaxis induced by A. actinomycetemcomitans under IM pretreatment. In the present study, we demonstrated that IM inhibited the A. actinomycetemcomitans-induced inflammatory response in gingival epithelium by suppressing neutrophil migration in vivo and in vitro. In addition, IM recovered the A. actinomycetemcomitans-induced reduction in E-cadherin, suggesting enhancement of the barrier function of gingival epithelium. In conclusion, IM may control A. actinomycetemcomitans-induced gingival inflammation by regulating neutrophil migration and E-cadherin expression in gingival epithelium.