Development of Chiral Azolium Salts as a Phase-Transfer Catalyst

手性唑鎓盐作为相转移催化剂的开发

• 批准号: 20850021
• 负责人: OHMATSU Kohsuke
• 金额: $ 2.1万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20850021/
• 关键词: 有機分子触媒; 不斉合成; オニウム塩; 相間移動触媒

A series of chiral triazolium salts have been designed as a new class of chiral phase-transfer catalyst, and readily prepared from easily available optically pure α-amino acids. The reactivity and selectivity of these chiral triazolium salts as chiral phase-transfer catalysts have been evaluated in the asymmetric cyanation and alkylation under mild liquid-liquid phase-transfer conditions.

设计了一系列手性三唑盐作为一类新型的手性相转移催化剂，并以易得的光学纯α-氨基酸为原料制备了手性三唑盐。考察了这些手性三唑盐作为手性相转移催化剂在温和的液-液相转移条件下的不对称氰化和烷基化反应的活性和选择性。