The expectation of aromatase inhibitor as a strategy for treatment of Japanese female pulmonary adenocarcinoma

芳香酶抑制剂作为日本女性肺腺癌治疗策略的期待

• 批准号: 20890014
• 负责人: ABE Keiko
• 金额: $ 2.11万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (Start-up)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20890014/
• 关键词: 肺癌; 女性; アロマターゼ; ホルモン受容体

Highly concordant coexpression of estrogen receptor beta and aromatase, one of the estrogen-producing enzyme, was observed among non-small cell carcinoma of the lung. Pulmonary adenocarcinoma, which is the most frequently observed among Japanese female lung cancer patients, is divided into two categories, such as bronchio-alveolar carcinoma (BAC) and non-BAC. BAC is defined as non-invasive adenocarcinoma by WHO criteria, otherwise non-BAC is invasive carcinoma and has more malignant potential. The co-expression of both aromatase and ER beta was more frequently observed among non-BAC of the lung. Furthermore, the proportion of ER beta in non-BAC of the lung was correlated with the proliferative activity of cancer cells.

在非小细胞肺癌中观察到雌激素受体β和芳香化酶（雌激素产生酶之一）的高度一致性共表达。肺腺癌是日本女性肺癌患者中最常见的，分为两类，如支气管肺泡癌（BAC）和非BAC。BAC按WHO标准定义为非浸润性腺癌，否则非BAC为浸润性癌，具有更高的恶性潜能。芳香化酶和ER β的共表达在肺非BAC中更常见。此外，ER β在肺的非BAC中的比例与癌细胞的增殖活性相关。

项目成果

Estrogen receptors and aromatase in Japanese female patients with pulmonary adenocarcinoma : a comparison between BAC and non-BAC

日本女性肺腺癌患者的雌激素受体和芳香酶：BAC 与非 BAC 的比较

• 发表时间: 2009
• 作者: K Abe;Y Miki;K Ono;N Kikuchi;T Takahashi;H Sasano
• 通讯作者: H Sasano

High concordant expression of aromatase and estrogen receptor beta in non-small lung cancer

非小细胞肺癌中芳香酶和雌激素受体β的高度一致表达

• 发表时间: 2008
• 作者: K Abe;Y Miki;K Ono;H Sasano
• 通讯作者: H Sasano

Highly concordant coexpression of aromatase and estrogen receptor beta in non-small cell lung cancer.

非小细胞肺癌中芳香酶和雌激素受体β高度一致的共表达。

• 发表时间: 2010
• 期刊: Hum Pathol. 41
• 作者: Abe K;Miki Y;Ono K;Mori M;Kakinuma H;Kou Y;Kudo N;Koguchi M;Niikawa H;Suzuki S;Evans DB;Sugawara S;Suzuki T;Sasano H.
• 通讯作者: Sasano H.

女性肺腺癌組織におけるステロイド受容体およびアロマターゼ発現の免疫組織化学的検討

女性肺腺癌组织中类固醇受体和芳香酶表达的免疫组织化学研究

• 发表时间: 2009
• 作者: 菊池直彦;阿部佳子;三木康宏;小野克彦;鈴木聡;高橋徹;笹野公伸
• 通讯作者: 笹野公伸

HIGH CONCORDANT EXPRESSION OF AROMATASE AND ESTROGEN RECEPTOR β IN NON-SMALL CELL LUNG CANCER

非小细胞肺癌中芳香酶和雌激素受体 β 的高度一致表达

• 发表时间: 2008
• 作者: Ohuchi N;Kawai M.;阿部佳子
• 通讯作者: 阿部佳子