The expectation of aromatase inhibitor as a strategy for treatment of Japanese female pulmonary adenocarcinoma

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Highly concordant coexpression of estrogen receptor beta and aromatase, one of the estrogen-producing enzyme, was observed among non-small cell carcinoma of the lung. Pulmonary adenocarcinoma, which is the most frequently observed among Japanese female lung cancer patients, is divided into two categories, such as bronchio-alveolar carcinoma (BAC) and non-BAC. BAC is defined as non-invasive adenocarcinoma by WHO criteria, otherwise non-BAC is invasive carcinoma and has more malignant potential. The co-expression of both aromatase and ER beta was more frequently observed among non-BAC of the lung. Furthermore, the proportion of ER beta in non-BAC of the lung was correlated with the proliferative activity of cancer cells.