Development of sensory genomics for evaluation of the molecular basis of taste response and palatability distinction

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Using mice with a WGA tracer introduced, we analyzed the genes expressions in taste cells, taste neurons and cerebral cells by transcriptome, and revealed the molecular properties of geniculate ganglion (GG), petrosal ganglion (PG), and nucleus of the solitary tract (NST) WGA-positive neurons transmitting from sweet/umami taste- and bitter taste-receiving cells. We also constructed transgenic medaka fish whose amino acid-receiving (T1Rs-positive) and bitter taste-receiving (T2Rs-positve) cells were made to have the WGA, and succeeded in visualizing their taste-transmitting pathways.