The role of S.aureus bacterial antigen in the pathogenesis of IgA nephritis

金黄色葡萄球菌细菌抗原在IgA肾炎发病机制中的作用

• 批准号: 20590960
• 负责人: KOYAMA Akio
• 金额: $ 3万
• 依托单位: Ibaraki Prefectural University of Health Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590960/
• 关键词: IgA腎症; ブドウ球菌細胞膜抗原; 低親和性IgA抗体; 高応答性抗体産生; IgA関連腎炎; 紫斑病性腎炎; MRSA感染後腎炎(スーパー抗原関連腎炎); TCRV βrepertoire; FACS解析; T細胞サブセット; T細胞活性化機序; MRSA感染後腎炎(スーパー抗原関連腎炎:SARN); TCRV β repertoire; T細胞subsets; ヒトIgA腎症; MRSA関連腎症; ブドウ球菌膜抗原; 高応答抗体産生性; IgA免疫複合体沈着

IgA nephropathy (IgAN) is the commonest glomerulonephritis in Asia, including Japan, characterized by the predominant deposition of IgA in the glomerulus. But the origin of this IgA and the mechanisms for its deposition remains unknown. In this study, we have shown that excessive production of circulating low-avidity antibodies against S.aureus cell envelope antigen in patient with IgAN, which may form immune complexes and accumulate in glomerular mesangial area. The lymphocytes subsets in patient with IgAN was analyzed as well, especially focusing on T cell antigen receptors repertoire using FACScan. These data suggest that immune abnormalities against S.aureus bacterial antigen may be involved in the pathogenesis of IgAN.

IgA肾病（IgAN）是包括日本在内的亚洲地区最常见的肾小球肾炎，其特征是肾小球中主要的IgA沉积。但这种IgA的起源及其沉积机制仍不清楚。在这项研究中，我们发现IgAN患者循环中过量产生针对金黄色葡萄球菌细胞包膜抗原的低亲和力抗体，这种抗体可能形成免疫复合物并积聚在肾小球系膜区。我们还分析了IgAN患者的淋巴细胞亚群，特别是使用FACScan检测T细胞抗原受体。这些数据表明，对金黄色葡萄球菌细菌抗原的免疫异常可能参与IgAN的发病机制。

项目成果

Serum ration of soluble triggering receptor expressed on myeloid cells-1 to creatinine is a useful marker of infectious complications in myeloperoxidase-antineutrophil cytoplasmic antibody-associated renal vasculitis.

骨髓细胞-1 上表达的可溶性触发受体与肌酐的血清比率是髓过氧化物酶-抗中性粒细胞胞质抗体相关性肾血管炎感染并发症的有用标志。

• 发表时间: 2011
• 期刊: Nephrol Dial Transplant 26
• 作者: Hirayama K;Koyama A;et al.
• 通讯作者: et al.

Protease activated receptor blocking peptide counteracts endotoxin-induced inflammation and coagulation and ameliorates renal fibrin deposition in a rat model of acute renal failure.

蛋白酶激活受体阻断肽可以抵消内毒素诱导的炎症和凝血，并改善急性肾衰竭大鼠模型中的肾纤维蛋白沉积。

• 发表时间: 2009
• 期刊: Shock 32
• 作者: Jesmin S;Yamaguchi N;et al.
• 通讯作者: et al.

コメデイカルのためのCKD慢性腎臓病療養指導マニュアル

CKD慢性肾脏病医师治疗指导手册

• 发表时间: 2010
• 作者: 山口直人;鹿野直人;小山哲夫
• 通讯作者: 小山哲夫

The expression of 4 protease-activated receptors is associated with increased levels of TNF-alpha, tissue factor, and fibrin in the frontal cortex of endotoxemic rats

4种蛋白酶激活受体的表达与内毒素血症大鼠额叶皮质中TNF-α、组织因子和纤维蛋白水平升高相关

• 发表时间: 2009
• 期刊: Thrombosis Research 124
• 作者: Jesmin S/Yamaguchi N;et al
• 通讯作者: et al

Anti-glomerular basement membrane antibody disease in Japan : part of the nationwide rapidly progressive glomerulonephritis suevey in Japan.

日本抗肾小球基底膜抗体病：日本全国快速进展性肾小球肾炎调查的一部分。

• 发表时间: 2008
• 期刊: Clin Exp Nephrol 12
• 作者: Hirayama K;Yamagata K;Koyama A;et al.
• 通讯作者: et al.