The role of S.aureus bacterial antigen in the pathogenesis of IgA nephritis

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IgA nephropathy (IgAN) is the commonest glomerulonephritis in Asia, including Japan, characterized by the predominant deposition of IgA in the glomerulus. But the origin of this IgA and the mechanisms for its deposition remains unknown. In this study, we have shown that excessive production of circulating low-avidity antibodies against S.aureus cell envelope antigen in patient with IgAN, which may form immune complexes and accumulate in glomerular mesangial area. The lymphocytes subsets in patient with IgAN was analyzed as well, especially focusing on T cell antigen receptors repertoire using FACScan. These data suggest that immune abnormalities against S.aureus bacterial antigen may be involved in the pathogenesis of IgAN.