Identifications for molecular mechanisms of essential hypertension in terms of urinary tubular ion transporter and human NEDD4L.

从尿管离子转运蛋白和人 NEDD4L 角度鉴定原发性高血压的分子机制。

• 批准号: 20590978
• 负责人: ISHIGAMI Tomoaki
• 金额: $ 3.16万
• 依托单位: Yokohama City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20590978/
• 关键词: 尿細管; ナトリウム輸送; Nedd4L; 本態性高血圧症; 心腎連関; 食塩感受性; イオントランスポーター; ナトリウムチャンネル; 尿細管レニンアンジオテンシン系; 上皮性ナトリウムチャンネル; 腎臓尿細管; ユビキチン化; NPC2; イオンチャンネル; ユビキチン

Nedd4L has been paid attention for its unique ubiquitinating properties that does an important working to cuticle sodium channel (ENaC) in the tubular epithelial cell and the post-transcriptional modification so far. Clarification and study results of the urinary tubular sodium re-absorption mechanism, and the role of Nedd4L in cardio-renal relationship is examined and the research announcement is done.

到目前为止，Nedd4L因其独特的泛素化特性在肾小管上皮细胞角质化钠通道(ENaC)和转录后修饰中发挥着重要作用而备受关注。澄清和研究了尿小管钠重吸收机制，以及Ned4L在心肾关系中的作用，并进行了研究公告。

项目成果

Combining chronic kidney disease with 201thallium/123iodine beta methlyiodophenly pentadecanoic acid dual myocardial single-photon emission computed tomography findings is useful for the evaluation of cardiac event risk.

将慢性肾脏疾病与 201 铊/123 碘 β 甲基碘苯十五烷酸双心肌单光子发射计算机断层扫描结果相结合，可用于评估心脏事件风险。

• 发表时间: 2009
• 期刊: Nucl Med Commun 30
• 作者: Takamura;T;Ishigami;T;et al.
• 通讯作者: et al.

ALDOSTERONE INDEPENDENT ACTIVATION OF MINERALCORTIC OID RECEPTOR-SGK1 SYSTEMS IN URINARY EPITHELIUM FOR THE MODEL OF SODIUM SENSITIVE HYPERTENSION

醛固酮独立激活钠敏感性高血压模型尿上皮中盐皮质激素受体-SGK1系统

• 发表时间: 2010
• 作者: Ushio H;Ishigami T;et al.
• 通讯作者: et al.

Expression of angiotensin II type 1 receptor-interacting molecule in normal human kidney and IgA nephropathy

• DOI: 10.1152/ajprenal.00667.2009
• 发表时间: 2010-10-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
• 影响因子: 4.2
• 作者: Masuda, Shin-ichiro;Tamura, Kouichi;Umemura, Satoshi
• 通讯作者: Umemura, Satoshi

Combining chronic kidney disease with201thallium/123iodine beta methyliodophenyl pentadecanoic acid dual myocardial single-photon emission computed tomography findings is useful for the evaluation of cardiac event risk.

将慢性肾病与 201 铊/123 碘 β 甲基碘苯基十五烷酸双心肌单光子发射计算机断层扫描结果相结合，可用于评估心脏事件风险。

• 发表时间: 2009
• 期刊: Nucl Med Commun. 30(1)
• 作者: Takamura T;Takahashi N;Ishigami T;Sugano T;Ishikawa T;Uchino K;Kimura K;Inoue T;Umemura S.
• 通讯作者: Umemura S.

ALDOSTERONE INDEPENDENT ACTIVATION OF MINERALCORTICOID RECEPTOR-SGK1 SYSTEMS IN URINARY EPITHELIUM FOR THE MODEL OF SODIUM SENSITIVE HYPERTENSION

钠敏感性高血压模型中醛固酮独立激活尿上皮盐皮质激素受体-SGK1系统

• 发表时间: 2010
• 作者: Ushio H;Ishigami T;et al.
• 通讯作者: et al.