Regression of hypertension : molecular analysis and epigenetic assessment

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Hypertension is the most prevalent disease in Japan, and affects at least one in four of the general population. Although hypertension is considered to be a progressive, irreversible disease, we demonstrated in this study that reversal or regression of hypertension may be feasible in animal models of hypertension. Regression of hypertension was achieved by 'pulse' treatment with an angiotensin receptor blocker at 10-50 times the normal dose, by a mechanism involving reversal of renal arteriolar hypertrophy.