Stat3 phosphorylation in pathogenesis of chronic cerebral ischemia

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An increase in serum cytokine level has been reported in acute ischemic stroke patients by many investigators. Among the various molecules involved in the JAK-STAT pathway activated by cytokine, Stat3 is the most important and has attracted much attention. We have already proven that Stat3 phosphorylation is associated with neuroprotection against acute cerebral ischemia. The neuroprotective effects of Stat3 phosphorylation are also supported by other reports. We observed the rapid enhancement of Stat3 phosphorylation was detected after the injection of high-dose recombinant LIF into the cerebral cortex on the ischemic side in rat focal ischemia. We examined the possible treatment strategy using Stat3 phosphorylation over a longer period, such as the first 2-3 months after cerebral ischemia using selective pharmacological agents of this signaling. However, we failed to prove definitive effects of Stat3 phosphorylation in chronic cerebral ischemia. This reason may be explained that Stat3 protein can be activated by a variety of signals, including other growth factors, cytokines, and oxidative stress