Cell therapy using adipose tissue-derived mesenchymal stem cells for primary myelofibrosis

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Mesenchymal stem cells (MSCs) have emerged as a new therapeutic modality for reconstituting the hematopoietic microenvironment. However, the availability of conventional bone marrow (BM)-derived MSCs (BMSCs) is limited. Recent studies showed that a large number of MSCs could be easily isolated from fat tissue (adipose tissue-derived MSCs [ADSCs]). We extensively evaluated the hematopoiesis-supporting properties of mouse ADSCs. Mouse ADSCs injected into the BM cavity of fatally irradiated mice reconstituted hematopoiesis more promptly than mouse BMSCs and subsequently rescued mice that had received a low number of HSCs. Human ADSCs possessed the higher hematopoiesis-supporting properties than human BMSCs as well.