A New treatment strategy using analysis of anti-transcriptional factors antibody in connective tissue diseases.

利用结缔组织疾病抗转录因子抗体分析的新治疗策略。

• 批准号: 20591179
• 负责人: SAITO Kazuyoshi
• 金额: $ 2.91万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591179/
• 关键词: 膠原病学; 抗転写因子抗体; 膠原病; 転写因子; 自己抗体

We developed a new detection system for anti-body against transcriptional factors in connective tissue diseases. Ninety six nuclear factors that involved in cell cycle and homeostasis were blotted on the DEAE paper and incubated with serum from the patients with connective tissue diseases including SLE, dermatomyositis, polyangitis. Anti-HMG1 antibody was detected in 2 patients with polyangitis. Antibody against PCNA was observed in 2 SLE but the serum reacted with a lot of nuclear factors irrelevant with organ specificity. Acetylation and methylation of nuclear factors did not affect on the result of detection of auto-antibody.

我们开发了一种新的结缔组织疾病转录因子抗体检测系统。在DEAE纸上印迹了96个参与细胞周期和稳态的核因子，并与SLE、皮肌炎、多血管炎等结缔组织疾病患者的血清孵育。2例多血管炎患者检测到抗hmg1抗体。2例SLE患者均检测到PCNA抗体，但血清与许多与器官特异性无关的核因子发生反应。核因子的乙酰化和甲基化对自身抗体检测结果无影响。

项目成果

Humanized anti human Interlukin-6 receptor monoclonal antibody tocilizumab (TCZ) increases high molecular weight adiponectin (HMW-AN) in the patients with rheumatoid arthritis (RA) : result from The ESCORT study

人源化抗人白介素 6 受体单克隆抗体托珠单抗 (TCZ) 增加类风湿性关节炎 (RA) 患者的高分子量脂联素 (HMW-AN)：来自 ESCORT 研究的结果

• 发表时间: 2010
• 作者: Saito K;Hanami k;Nawata M;Yunoue N;Tanaka Y
• 通讯作者: Tanaka Y

Etanercept overcomes P-glycoprotein-induced drug resistance in lymphocytes of patients with intractable rheumatoid arthritis

• DOI: 10.3109/s10165-009-0247-0
• 发表时间: 2010-04
• 期刊: Modern Rheumatology
• 影响因子: 2.2
• 作者: S. Tsujimura;K. Saito;S. Nakayamada;Yoshiya Tanaka

Etanercept overcomes P-glycoprotein-induced drug resistance in lymphocytes of patients with intractable rheumatoid arthritis

• DOI: 10.1007/s10165-009-0247-0
• 发表时间: 2010-04-01
• 期刊: MODERN RHEUMATOLOGY
• 影响因子: 2.2
• 作者: Tsujimura, Shizuyo;Saito, Kazuyoshi;Tanaka, Yoshiya
• 通讯作者: Tanaka, Yoshiya

Effects of anti-TNF-alpha antibody infliximab in refractory entero-Behcet's disease.

抗 TNF-α 抗体英夫利昔单抗在难治性肠白塞氏病中的作用。

• 发表时间: 2009
• 期刊: Rheumatology 48(8)
• 作者: Iwata S;Saito K;Yamaoka K;Tsujimura S;Nawata M;Suzuki K;Tanaka Y
• 通讯作者: Tanaka Y

Humanized anti-human Intedukin-6 receptor monoclonal antibody tocilizumab(TCZ)increases high molecules weight adiponectin(HMW-AN)in the patients with rheumatoid arthritis(RA): result from The ESCORT study

人源化抗人 Intedukin-6 受体单克隆抗体托珠单抗 (TCZ) 增加类风湿性关节炎 (RA) 患者的高分子量脂联素 (HMW-AN)：来自 ESCORT 研究的结果

• 发表时间: 2010
• 作者: Kawashiri S;Kawakami A;et al.(2番目;他12名);Saito K
• 通讯作者: Saito K