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A New treatment strategy using analysis of anti-transcriptional factors antibody in connective tissue diseases.

A New treatment strategy using analysis of anti-transcriptional factors antibody in connective tissue diseases.
利用结缔组织疾病抗转录因子抗体分析的新治疗策略。
批准号：
20591179
负责人：
SAITO Kazuyoshi
金额：
$2.91万
依托单位：
University of Occupational and Environmental Health, Japan
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
项目状态：
已结题
起止时间：
2008 至 2010
来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591179/
关键词：
膠原病学抗転写因子抗体膠原病転写因子自己抗体

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英文摘要
We developed a new detection system for anti-body against transcriptional factors in connective tissue diseases. Ninety six nuclear factors that involved in cell cycle and homeostasis were blotted on the DEAE paper and incubated with serum from the patients with connective tissue diseases including SLE, dermatomyositis, polyangitis. Anti-HMG1 antibody was detected in 2 patients with polyangitis. Antibody against PCNA was observed in 2 SLE but the serum reacted with a lot of nuclear factors irrelevant with organ specificity. Acetylation and methylation of nuclear factors did not affect on the result of detection of auto-antibody.
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会议论文
Humanized anti human Interlukin-6 receptor monoclonal antibody tocilizumab (TCZ) increases high molecular weight adiponectin (HMW-AN) in the patients with rheumatoid arthritis (RA) : result from The ESCORT study
人源化抗人白介素 6 受体单克隆抗体托珠单抗 (TCZ) 增加类风湿性关节炎 (RA) 患者的高分子量脂联素 (HMW-AN)：来自 ESCORT 研究的结果
DOI： --
发表时间： 2010
期刊：
影响因子： --
作者： [Saito K, Hanami k, Nawata M, Yunoue N, Tanaka Y]
通讯作者： Tanaka Y
Etanercept overcomes P-glycoprotein-induced drug resistance in lymphocytes of patients with intractable rheumatoid arthritis
DOI： 10.3109/s10165-009-0247-0
发表时间： 2010-04
期刊： Modern Rheumatology
影响因子： 2.2
作者： [S. Tsujimura;K. Saito;S. Nakayamada;Yoshiya Tanaka]
通讯作者： S. Tsujimura;K. Saito;S. Nakayamada;Yoshiya Tanaka
Etanercept overcomes P-glycoprotein-induced drug resistance in lymphocytes of patients with intractable rheumatoid arthritis
DOI： 10.1007/s10165-009-0247-0
发表时间： 2010-04-01
期刊： MODERN RHEUMATOLOGY
影响因子： 2.2
作者： [Tsujimura, Shizuyo, Saito, Kazuyoshi, Tanaka, Yoshiya]
通讯作者： Tanaka, Yoshiya
Effects of anti-TNF-alpha antibody infliximab in refractory entero-Behcet's disease.
抗 TNF-α 抗体英夫利昔单抗在难治性肠白塞氏病中的作用。
DOI： --
发表时间： 2009
期刊： Rheumatology 48(8)
影响因子： --
作者： [Iwata S, Saito K, Yamaoka K, Tsujimura S, Nawata M, Suzuki K, Tanaka Y]
通讯作者： Tanaka Y
共 10 条
    Novel strategies for treatment of rheumatic diseases by Wnt signal blockades
    Involvement of Epithelial and endothelial to mesenchymal transition in tissue remolding of rheumatic diseases
    The mechanism of inflammation in autoimmune response during the acute phase of Kawasaki disease.
    • 批准号：
      22790969
    • 项目类别：
      Grant-in-Aid for Young Scientists (B)
    • 资助金额：
      $2.5万
    • 财政年份：
      2010
    • 负责人：
      SAITO Kazuyoshi
    • 依托单位：
      University of Toyama
    Therapeutic strategy for inflammatory diseases by a novel negative regulatory transcriptional factor of inflammatory cytokines