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Chemical and crystallographic characteristics and growth factors of calcium carbonate gallstones.

碳酸钙胆结石的化学和晶体学特征以及生长因子。

基本信息

批准号：
02670586
负责人：
SAITO Kazuyoshi
金额：
$ 1.41万
依托单位：
Iwate Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1990
资助国家：
日本
起止时间：
1990 至 1991
项目状态：
已结题

项目摘要

1) Crystallographic studies by Infrared-spectrophotometry and X-ray diffractometry. . .(1) In calcium-carbonate gallstones, aragonite was most commonly found, with an occurrence rate of 90.6%, and that of calcite was 62.5%. Even vaterite was found In 28.1%. In nature, the most stable calcite is most commonly found but in our CaCo_3-Gallstone series aragonite was dominant.(2) In black stones with liver cirrhosis, calcite was found In all cases, but stones without liver cirrhosis aragonite was found in 75%.(3) In pancreatic stones calcite was found In 3 out of 4 cases.2) Differential Thermal Analysis (DTA) of CaCO_3, aragonite fors. . .Calcareous sinter completed its conversion into calcite at 500ﾟC, while In gallstones only 8% transformed into calcite, 56% at 600ﾟC and 69% even at 650ﾟC.3) Experimental Production of CACO_3. . .The crystalline compositions of synthesized calcium carbonate changed according to the calcium ion concentration of the mother solution. When the initial calcium ion concentration was less than 140ppm, and when no bile powder was added only aragonite was precipitated.4) Inorganic and Organic Ion Components. . .In calcium carbonate gallstone series, Na, K. and Mg averaged 0.66%, 0.07%, and 0.09%, respectively. Aragonite group had a tendency to be less in Mg-ion. Organic component was 17.8%.5) It was considered that coexisting materials and environmental factors may control the crystallization, and the organic material may cause the crystallographic stability.

1)用分光光度法和X射线衍射法进行晶体学研究。. . (1)碳酸钙结石中以文石最常见，占90.6%，方解石占62.5%。偶见球文石28.1%。在自然界中，最稳定的方解石是最常见的，但在我们的CaCo_3-胆石系列中，文石占主导地位。(2)肝硬化组黑色结石均见方解石，非肝硬化组结石75%见文石。(3)胰结石中有3例为方解石。.石灰质烧结矿在500 ℃时完全转化为方解石，而胆结石中只有8%转化为方解石，600 ℃时为56%，650 ℃时为69%。.合成碳酸钙的结晶组成随母液中钙离子浓度的变化而变化。当初始钙离子浓度小于140 ppm时，不加胆汁粉时，只沉淀出文石。4）无机和有机离子成分。.在碳酸钙结石系列中，Na、K。Mg平均含量分别为0.66%、0.07%和0.09%。文石组有镁离子含量较少的趋势。有机物含量为17.8%。5）认为共存物质和环境因素可能控制了结晶，有机物可能导致结晶的稳定性。