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The neural substrate of stereotypic behaviors in patients with frontotemporal dementia

额颞叶痴呆患者刻板行为的神经基础

基本信息

批准号：
20591414
负责人：
IKEDA Manabu
金额：
$ 3万
依托单位：
Kumamoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2008
资助国家：
日本
起止时间：
2008 至 2010
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591414/
关键词：
常同行動 FTD 神経基盤統計画像解析 SPECT 食行動 Semantic Dementia Progressive supranuclear palsy Semantic dementia

项目摘要

Recently, the relationship between Progressive supranuclear palsy (PSP) and frontotemporal dementia (FTD) has been recognized, which includes clinical, pathological, biochemical and genetic features. However, there have been few studies that directly compared neuropsychiatric symptoms between PSP and FTD. The aim of the present study was to investigate comprehensive psychiatric and behavioral symptoms in PSP and compared them with those in FTD. Patients with PSP (n=10) and FTD (n=13) were selected on the basis of inclusion/exclusion criteria from a consecutive series in the dementia clinic of Kumamoto University Hospital. We assessed their comprehensive neuropsychiatric features by using the Neuropsychiatric Inventory (NPI), the Stereotypy Rating Inventory (SRI) and a specific antisocial behavior checklist. There were no significant differences in the total NPI and NPI subscale scores between the two groups. Both groups showed quite asimilar pattern in the features of neuropsychiatric symptoms : apathy showed the highest score, followed by aberrant motor behavior and disinhibition.The PSP group was significantly lower in the total SRI and eating and cooking behavior scores than those in the FTD group. The prevalence of antisocial behaviors in PSP (50%) was equal to those in the FTD group (46%). We hypothesize that the stereotypic behaviors reflect the involvement of specific neural substrate in FTD-namely, the ventral frontal lobe, the temporal pole, and the amygdala.

近年来，进行性核上性麻痹（PSP）与额颞叶痴呆（FTD）之间的关系已被认识到，包括临床、病理、生化和遗传等方面的特征。然而，很少有研究直接比较PSP和FTD之间的神经精神症状。本研究的目的是探讨PSP患者的综合精神和行为症状，并将其与FTD患者进行比较。根据纳入/排除标准从熊本大学医院痴呆门诊的连续系列患者中选择PSP （n=10）和FTD （n=13）患者。我们使用神经精神量表（NPI）、刻板印象评定量表（SRI）和特定的反社会行为检查表来评估他们的综合神经精神特征。两组在NPI总得分和NPI亚量表得分上无显著差异。两组在神经精神症状特征上表现出非常相似的模式：冷漠得分最高，其次是异常运动行为和去抑制。PSP组在总SRI和饮食和烹饪行为得分上明显低于FTD组。PSP组的反社会行为患病率（50%）与FTD组的患病率（46%）相等。我们假设刻板行为反映了ftd中特定神经基质的参与，即腹侧额叶、颞极和杏仁核。