Neural correlate of abnormal eating behavior in semantic dementia

语义痴呆异常饮食行为的神经相关性

• 批准号: 23591718
• 负责人: IKEDA Manabu
• 金额: $ 3.24万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23591718/
• 关键词: 老年精神医学; 神経回路; 認知症; 前頭側頭型認知症; 意味性認知症; 食行動; 過食; 異食; 嗜好; 神経基盤

As is well known, patients with frontotemporal lobar degeneration (FTLD) show various abnormal eating behaviors. However there are few researches focused on eating behavior in semantic dementia (SD) that is a clinical subtype of FTLD. Subjects were 19 SD patients, in which assessment scale of eating behaviors and brain SPECT were undergone. The assessment scale consists of 5 domains: swallowing problem, appetite change, food preference, eating habits and other oral behaviors. Semi-quantitative methods were used to assess rCBF changes. Regional tracer uptake was measured in region of interest (ROI) over the bilateral superior and inferior frontal cortex, lateral and medial temporal cortex, thalamus and cerebellum, and calculated ROI ratios divided by ROI in cerebellum. Using partial correlation analysis adjusted by duration of illness showed significant correlations between right frontal cortex and increased appetite, and between bilateral temporal cortex and changes of food preference.

众所周知，额颞叶变性（FTLD）患者表现出各种异常的饮食行为。然而，很少有研究关注FTLD的临床亚型--语义性痴呆（SD）的饮食行为。以19例SD患者为研究对象，进行饮食行为评定量表和脑SPECT检查。评估量表包括5个领域：吞咽问题，食欲变化，食物偏好，饮食习惯和其他口腔行为。半定量方法用于评估rCBF变化。在双侧上级和下级额叶皮质、外侧和内侧颞叶皮质、丘脑和小脑的感兴趣区域（ROI）中测量局部示踪剂摄取，并计算ROI比除以小脑中的ROI。经病程调整后的偏相关分析显示，右额叶皮层与食欲增加显著相关，双侧颞叶皮层与食物偏好变化显著相关。

项目成果

Multicenter population‐based study on the prevalence of early onset dementia in Japan: Vascular dementia as its prominent cause

日本早发性痴呆患病率的多中心人群研究：血管性痴呆是其主要原因

• DOI: 10.1111/pcn.12127
• 发表时间: 2014
• 期刊: Psychiatry and Clinical Neurosciences
• 影响因子: 11.9
• 作者: Chiaki Ikejima;M. Ikeda;M. Hashimoto;Yusuke Ogawa;S. Tanimukai;Tetsuo Kashibayashi;K. Miyanaga;Kimie Yonemura;T. Kakuma;K. Murotani;T. Asada
• 通讯作者: T. Asada

Prevalence of delirium among outpatients with dementia

• DOI: 10.1017/s1041610213001191
• 发表时间: 2013-11-01
• 期刊: INTERNATIONAL PSYCHOGERIATRICS
• 影响因子: 7
• 作者: Hasegawa, N.;Hashimoto, M.;Ikeda, M.
• 通讯作者: Ikeda, M.

Maluticenter population-based study on the prevalence of early onset dementia in Japan: Vascular dementia as its prominent cause

Maluticenter 基于人群的日本早发性痴呆患病率研究：血管性痴呆是其主要原因

• 发表时间: 2014
• 期刊: Psychiatry and Clinical Neurosciences
• 影响因子: 11.9
• 作者: Ikejima C;Ikeda M;Hashimoto M;Ogawa Y;Tanimukai S;Kashibayashi T;Miyanaga K;Yonemura K;Kakuma T;Morotani K;Asada T
• 通讯作者: Asada T

Is sense of coherence helpful in coping with caregiver burden for dementia?

连贯感有助于应对痴呆症护理人员的负担吗？

• DOI: 10.1111/psyg.12050
• 发表时间: 2014
• 期刊: Psychogeriatrics
• 影响因子: 2
• 作者: Matsushita M;Ishikawa T;Koyama A;Hasegawa N;Ichimi N;Yano H;Hashimoto M;Fujise N;Ikeda M.
• 通讯作者: Ikeda M.

The relationship between primary progressive aphasia and neurodegenerative dementia

原发性进行性失语与神经退行性痴呆的关系

• 发表时间: 2013
• 期刊: East Asian Arch Psychiatry
• 作者: Ichimi N;Hashimoto M;Matsushita M;Yano H;Yatabe Y;Ikeda M
• 通讯作者: Ikeda M