Development of the integrated system for the analysis of brain function by high resolution micro-PET for small animals using high field MRI

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The high-resolution PET for small animals is expected to be one of the important tools for the elucidation of the pathophysiology and the innovative drug development of the disease. In this study, we tried to develop the system which enables us to analyze molecular target imaging by micro-PET using high-field MRI. We attempted to design a new head fixation device for mouse which can be used commonly both for micro-PET and high-field MRI for small animals, and made a digital mouse brain atlas for anatomic delineation on micro-PET imaging and MRI utilizing an atlas of stained brain sections of mice, on which each brain domain was separated by color. We applied this technique to the analysis of FDG-PET imaging of normal and transgenic mouse. The abnormal metabolic area on the FDG-PET image of the disease model mouse (DRPLA) was successfully identified using our newly developed system.