Novel high-field MRI compatible subdural electrode and acquisition system for recording and stimulation in small animals

新型高场 MRI 兼容硬膜下电极和采集系统，用于小动物的记录和刺激

• 批准号: 10325694
• 负责人: Hernan Millan
• 金额: $ 11.83万
• 依托单位: EMRI SYSTEMS LLP
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-13 至 2023-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10325694
• 关键词: Adhesions; Animal Experimentation; Animal Model; Animals; Area; Boston; Brain; Brain imaging; Clinical; Data; Disease; Drug abuse; Electrocorticogram; Electrodes; Electroencephalogram; Electroencephalography; Electromyography; Electrophysiology (science); Engineering; Epilepsy; Exposure to; Film; Fruit; Functional Magnetic Resonance Imaging; Gelfilm; General Hospitals; Genetic; Goals; Human; Image; Imaging Device; Implant; Lead; Legal patent; Magnetic Resonance Imaging; Massachusetts; Medicine; Miniaturization; Mission; Modification; Multimodal Imaging; Neurosciences; Patients; Performance; Phase; Polymers; Primates; Property; Publications; Rattus; Research; Safety; Stretching; Surface; System; Testing; Thick; Thinness; Tissues; Work; addiction; animal imaging; base; clinically significant; commercialization; data quality; flexibility; imaging approach; imaging study; imaging system; improved; innovation; nerve injury; neurosurgery; nonhuman primate; novel; open source; pre-clinical; prototype; relating to nervous system; source localization; tool

Abstract Preclinical small animal imaging makes valuable contributions to improving our understanding of human brain. Multi-modal imaging approaches to combine functional Magnetic Resonance Imaging (fMRI) with Intracranial Electroencephalogram (iEEG) provides an unparalleled view of the global network activity across cortical areas, revealing information at high temporal and spatial scales about functional connectivity and their intrinsic oscillatory properties, which is of vital importance in many branches of neuroscience and medicine. Despite this clear advantage, the use of iEEG-fMRI is limited in small animal research. The existing MRI compatible headstages on the market for small animals are inadequate to acquire high-fidelity iEEG-fMRI. Working within this premise, the long-term goal of this project is to develop a headstage for high-fidelity recording and stimulation in small animals. We propose to unlock high-fidelity iEEG-fMRI imaging paradigm leveraging our patented innovative MRI-compatible electrode- grid (PTFOS) which is based on organic-absorbable, stretchable, and conformable substrate for optimal safety, flexibility and performance with distinct advantages over other neural grids. Phase I of this application proposes to develop HF-2 acquisition prototype which will fit into animal MRI bore recording constraints and tests its feasibility in rats during high-field MRI (9.4Tesla) at Massachusetts General Hospital. Phase II focuses on adding stimulation module, commercialization and miniaturization of HF-2 into a tiny headstage.

摘要