The development of the noninvasive diagnostic method of the articular cartilage grafting with 3- tesla magnetic resonance imaging.

3-特斯拉磁共振成像关节软骨移植无创诊断方法的发展

• 批准号: 20591443
• 负责人: FUJII Mashiko
• 金额: $ 2.91万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591443/
• 关键词: 放射線; 再生医学; 病理学; 関節軟骨; 3T-MRI; T1ρ; T2 mapping

The histopathological findings of articular cartilage were compared with T2W images and T2 values in T2 mapping using 3T-MRI. As a result, it was considered that the increase of degenerative collagen was associated with the prolongation of T2 value. The deep layer and calcified layer of articular cartilage cannot be depicted by the conventional sequence because T2 values of these layers are too short. To depict these layers selectively, we developed an ultra short TE (μTE) sequence by cooperation of Hitachi Medico Co., Ltd. These layers were depicted as a hyperintense area by using μTE sequence. To evaluate the decrease of the cartilage matrix with the aging, the T1 ρ value of articular cartilage was measured in healthy volunteers. A strong positive relationship was recognized between an age and the T1 ρ values. It was considered that these data could be used as the normal database which evaluated a change with the aging of the cartilage matrix.

将关节软骨的组织病理学表现与3 T-MRI T2 W图像及T2值进行比较。因此，认为退行性胶原的增加与T2值的延长有关。关节软骨深层及钙化层T2值过短，常规序列不能显示。为了选择性地描述这些层，我们与Hitachi Medico Co.，这些层用μTE序列描绘为高信号区。为了评价软骨基质随年龄增长而减少的情况，测量了健康志愿者关节软骨的T1 ρ值。年龄与T1 ρ值之间存在较强的正相关。认为这些数据可用作评价软骨基质随老化的变化的正常数据库。

项目成果

【関節の画像診断の新たな展開】膝関節診断の話題

【关节影像诊断新进展】膝关节诊断专题

• 发表时间: 2010
• 期刊: 臨床画像 26
• 作者: 藤井正彦、岩間祐基、後藤一、黒田良祐;久保晴司;杉村和朗
• 通讯作者: 杉村和朗

Age related change and weight-bearing related change in the T1 rhovalue of normal knee cartilage using 3T-MRI : a preliminary study

使用 3T-MRI 观察正常膝关节软骨 T1 rho 值的年龄相关变化和负重相关变化：一项初步研究

• 发表时间: 2011
• 作者: Hajimu Goto;Masahiko Fujii;Yuki Iwama;et.al
• 通讯作者: et.al

超短TE(μTE)シークエンスを用いた関節軟骨の描出

使用超短 TE (μTE) 序列描绘关节软骨

• 发表时间: 2010
• 作者: 後藤一;藤井正彦;岩間祐基;青山信和;川光秀昭;大野良治;瀧澤将宏;小原陽子;加藤和之;杉村和朗
• 通讯作者: 杉村和朗

手関節における高分解能 kinematic MRI-健常ボランティアにおける検討-

腕关节的高分辨率运动学 MRI -健康志愿者的研究 -

• 发表时间: 2009
• 作者: 岩間祐基;藤井正彦;青山信和;川光秀昭;藤岡宏幸;増田智徳;小原陽子;杉村和朗
• 通讯作者: 杉村和朗

3T-MRIの現状と展望-関節軟骨(再生)の3T-MRI-

3T-MRI的现状与展望 - 关节软骨（再生）的3T-MRI -

• 发表时间: 2008
• 作者: Chiba K;Uetani M;Kido Y;Ito M;Okazaki N;Taguchi K;Shindo H;藤井正彦
• 通讯作者: 藤井正彦