The role of the adipocyte function in the gender-specific medicine after the surgical stress : the effectiveness of the pioglitazone administration

手术应激后脂肪细胞功能在性别特异性医学中的作用：吡格列酮给药的有效性

• 批准号: 20591537
• 负责人: MATSUTANI Takeshi
• 金额: $ 2.83万
• 依托单位: Nippon Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591537/
• 关键词: 外科総論; 手術侵襲; 性差医療; 脂肪細胞; ピオグリタゾン

Adipose tissue is considered to be an endocrine/immune organ secreting a variety of biologically active molecules, conceptualized as adipokines. However, the mechanism of gender-related alterations in the innate function of adipose tissue after major surgery is still unknown. The aim of this study was to investigate the effect of gender differences in innate inflammatory responses and the function of adipose tissue in patients undergoing major gastrointestinal gastrointestinal surgery. There were no significant differences in terms of age, operation time, or blood loss between male and female patients. However, the women had a significantly lower morbidity rate due to postoperative complication than did the men. Preoperative levels of adiponectin and leptin were lower in male patients than in female patients and postoperative adiponectin and leptin levels have clearly shown lower inflammatory responses in women after surgery. These findings suggest that male patients might develop postoperative immune suppression after major surgery, whereas female patients have an immunological advantage including adipose function during the early postoperative period.

脂肪组织被认为是一种内分泌/免疫器官，分泌各种生物活性分子，概念上称为脂肪因子。然而，大手术后脂肪组织先天功能性别相关改变的机制仍不清楚。本研究的目的是探讨先天性炎症反应和脂肪组织功能的性别差异在接受胃肠道手术的患者的影响。男性和女性患者在年龄、手术时间或失血量方面无显著差异。然而，由于术后并发症，女性的发病率明显低于男性。男性患者术前脂联素和瘦素水平低于女性患者，术后脂联素和瘦素水平明显显示女性术后炎症反应较低。这些结果表明，男性患者可能会在大手术后发生术后免疫抑制，而女性患者在术后早期具有免疫优势，包括脂肪功能。

项目成果

術前PPAR-γリガンド投与による抗炎症作用-マウス腹膜炎モデルにおける脂肪細胞機能に着目して-

术前PPAR-γ配体给药的抗炎作用 - 关注小鼠腹膜炎模型中的脂肪细胞功能 -

• 发表时间: 2010
• 作者: Sayako Miura-Takeda;Junko Tashiro-Yamaji;Hidehiro Oku;Takeshi Takahashi;Tetsunosuke Shimizu;Tetsuya Sugiyama;Tsunehiko Ikeda;Takahiro Kubota;Ryotaro Yoshida;松谷毅,内田英二,松田明久,丸山弘,鈴木成治,横山正,杉浦篤,松下晃,新井洋紀,笹島耕二
• 通讯作者: 松谷毅,内田英二,松田明久,丸山弘,鈴木成治,横山正,杉浦篤,松下晃,新井洋紀,笹島耕二

食道癌手術後の末梢血アディポネクチンとテストステロン値の関係

食管癌术后外周血脂联素与睾酮水平的关系

• 发表时间: 2008
• 作者: 松谷毅;笹島耕二;松田明久;ほか
• 通讯作者: ほか

脂肪関連mediatorとSSI発症の関連

脂肪相关介质与 SSI 发病之间的关联

• 发表时间: 2008
• 作者: 松田明久;松谷毅;ほか
• 通讯作者: ほか

脂肪細胞からみた手術侵襲後の生体防御反応と術後感染症

从脂肪细胞角度探讨手术侵袭后的生物防御反应与术后感染

• 发表时间: 2008
• 期刊: 成人病と生活習慣病 38
• 作者: 池田宏国;平成人;他;松田明久,松谷毅,笹島耕二,丸山弘,宮本昌之,横山正,鈴木成治,田村和広,向後博司,古川清憲,田尻孝
• 通讯作者: 松田明久,松谷毅,笹島耕二,丸山弘,宮本昌之,横山正,鈴木成治,田村和広,向後博司,古川清憲,田尻孝

PPARg attenuates inflammatory response through the activation of adipocyte in mice polymicrobial sepsis.

PPARg 通过激活多种微生物败血症小鼠的脂肪细胞来减轻炎症反应。

• 发表时间: 2009
• 作者: Matsuda A;Matsutani T;Sasajima K;et al.
• 通讯作者: et al.