Nutritional effects of the novel fat emulsion emulsified by phosphatidylglycerol after cirrhotic liver resection

新型磷脂酰甘油乳化脂肪乳对肝硬化肝切除术后的营养作用

• 批准号: 20591553
• 负责人: TAKIFUJI Katsunari
• 金额: $ 2.75万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591553/
• 关键词: 代謝栄養外科学; 脂肪乳剤; 外科栄養; 肝硬変

We established a novel fat emulsion emulsified by phosphatidylglycerol (PG) and evaluated the efficacy on nutritional management after cirrhotic liver resection in thioacetamide-treated rats. PG emulsion inhibited not only the increases in serum triglyceride and free fatty acids, but also inhibited increases in serum levels of phospholipids for 2 hours after rapid infusion、even in hepatectomized rats with liver cirrhosis. Thus, temporary hyperlipidemia did not occur. Triglycerides from PG emulsion transferred into the hepatic cells much more rapidly than existing emulsions emulsified by phosphatidylcholine. The infusion of PG emulsion maintained a high level of energy charge of the liver even in hepatectomized rats with liver cirrhosis. On the electron microscopic findings, PG emulsion was rapidly taken into the hepatic cells and metabolized. From the results of this study, a novel PG emulsion produced rapid clearance from the blood stream, rapid transfer into the hepatic cells, and efficacy in energy production in the hepatic cells. Thus, we speculated that a novel PG emulsion might be available for cirrhotic liver resection in which commercial fat emulsions are not used.

我们建立了一种新型的脂肪乳剂乳化磷脂酰甘油（PG）和硫代乙酰胺治疗大鼠肝切除术后的营养管理的疗效进行了评估。PG乳剂不仅抑制了血清甘油三酯和游离脂肪酸的增加，而且还抑制了快速输注后2小时的血清磷脂水平的增加，即使在肝切除的肝硬化大鼠中也是如此。因此，未发生暂时性高脂血症。PG乳剂中的甘油三酯转移到肝细胞的速度比现有的磷脂酰胆碱乳化乳剂快得多。PG乳剂的输注即使在肝硬化的肝切除大鼠中也维持了高水平的肝脏能量电荷。在电子显微镜下发现，PG乳剂被快速摄入肝细胞并代谢。根据本研究的结果，新型PG乳剂可从血流中快速清除，快速转移至肝细胞中，并在肝细胞中有效产生能量。因此，我们推测，一种新的PG乳剂可能可用于不使用商业脂肪乳剂的肝切除术。

项目成果

脂肪乳剤投与の意義

脂肪乳给药的意义

• 发表时间: 2010
• 期刊: 臨床栄養別冊(JCNセレクト4)
• 作者: 瀧藤克也;山上裕機;谷村弘
• 通讯作者: 谷村弘