Analyses of DNA damage response to neoadjuvant chemotherapy in basal-like breast cancer

基底细胞样乳腺癌新辅助化疗 DNA 损伤反应分析

• 批准号: 20591557
• 负责人: OHTA Tomohiko
• 金额: $ 2.91万
• 依托单位: St.Marianna University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591557/
• 关键词: BRCA1; Basal-like乳癌; DNA損傷; 薬剤感受性; 術前化学療法; 術前化学療; Basal-like 乳癌

Core needle biopsy specimens were obtained from sixty cases of primary breast cancer before and 18-24 hours after the first cycle of neoadjuvant epirubicin plus cyclophosphamide treatment. Nuclear focus formation of DNA damage repair proteins, BRCA1-, gH2AX-, or Rad51, was immunohistochemically analyzed and DNA damage response competence was evaluated as DDR score. A high DDR score significantly correlated with low tumor response to EC and EC + docetaxel whereas other clinicopathological factors analyzed did not.

60例原发性乳腺癌患者在新辅助表柔比星加环磷酰胺第一周期治疗前和治疗后18~24小时取芯针活检标本。用免疫组织化学方法分析DNA损伤修复蛋白BRCA1-、gH2AX-或RAD51的核焦点形成，并以DDR评分评估DNA损伤反应能力。DDR评分高与肿瘤对EC和EC+多西紫杉醇的低反应显着相关，而分析的其他临床病理因素则不相关。

项目成果

Radiologic-pathological correlation of punctate hyperechoic foci by ultrasound in stereotactic vacuum-assisted breast biopsy samples

• DOI: 10.1007/s11604-009-0367-7
• 发表时间: 2009-12-01
• 期刊: JAPANESE JOURNAL OF RADIOLOGY
• 影响因子: 2.1
• 作者: Okazaki, Hiroko;Tsujimoto, Fumio;Nakajima, Yasuo
• 通讯作者: Nakajima, Yasuo

Modification of the Hepatic Mito-chondrial Proteome in Response to Ischemic Preconditioning following Ischemia-Reperfusion Injury of the Rat Liver.

大鼠肝脏缺血再灌注损伤后肝脏线粒体蛋白质组的修饰对缺血预处理的反应。

• 发表时间: 2008
• 期刊: Eur Surg Res. 40
• 作者: Oshima R;Nakano H;Katayama M;Sakurai J;Wu W;Koizumi S;Asano T;Watanabe T;Asakura T;Ohta T;Otsubo T
• 通讯作者: Otsubo T

Involvement of kinesin family member 2C/mitotic centromere-associated kinesin overexpression in mammary carcinogenesis

• DOI: 10.1111/j.1349-7006.2007.00635.x
• 发表时间: 2008-01-01
• 期刊: CANCER SCIENCE
• 影响因子: 5.7
• 作者: Shimo, Arata;Tanikawa, Chizu;Katagiri, Toyomasa
• 通讯作者: Katagiri, Toyomasa

BAP1 interferes with BRCA1/BARD1 RING heterodimer activity.

BAP1 干扰 BRCA1/BARD1 RING 异二聚体活性。

• 发表时间: 2009
• 期刊: Cancer Res. 69
• 作者: Nishikawa H;Wu W;Koike A;Kojima R;Gomi H;Fukuda M;Ohta T.
• 通讯作者: Ohta T.

The ubiquitin E3 ligase activity of BRCA1 and its biological functions.

• DOI: 10.1186/1747-1028-3-1
• 发表时间: 2008-01-07
• 期刊: Cell division
• 影响因子: 2.3
• 作者: Wu W;Koike A;Takeshita T;Ohta T
• 通讯作者: Ohta T