Identification of epigenetic biomarkers in benign brain tumors in the post-genome era

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We analyzed exhaustive epigenetic changes of the meningioma, the most common brain tumor. Using microarrays that can analyze 6157 genomes, 15273 CpG islands, 20 WHO grade 1 and 10 grade 2 meningiomas were analyzed. The data showed 2 clusters, hypo-methylated and hyper-methylated groups, independent of WHO grading. Most invasive meningiomas and recurrent meningiomas were included in the hyper-methylated cluster. Our results suggest that epigenetic changes of DNA methylation reflect active nature, such as invasion or recurrence, of the meningiomas.