Targeted delivery of magnetic Iiposome encapsulated platelet rich plasma for bone formation in a rat bone-defect model

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The purpose of this study is to reconstruct a large bone defect by collecting Platelet rich plasma PRP encapsulated magnetic liposomes to the artificial bone with use of the external magnetic force and promoting bone formation and bone induction.A critical sized segmental bone defect (5mm) was created in the mid-part of the femoral shaft in a rat. An interconnected porous hydroxyapatite ceramic was intercalated in the bone defect and fixed by a 1.2mm kirschner-wire. There were three treatment groups, PRP only, PRP encapsulated magnetic liposomes only, and PRP encapsulated magnetic liposomes with external magnetic force. In the PRP group, new bone formation was well recognized radiologically and histologically than the non-PRP group.