Molecular mechanisms of regulation in bone and cartilage metabolism by GSK3β

Gsk3β参与了胰岛素/胰岛素样生长因子信号和典型的Wnt信号，在多种生物过程中发挥着重要作用。本研究探讨了GSK-3β调控骨代谢的分子机制。我们利用小鼠原代成骨细胞、软骨细胞和不同的细胞系，在生理或病理条件下对GSK3β缺陷小鼠的骨骼表型进行了分析，并进行了功能分析。我们阐明了Gsk3β在成骨细胞或软骨细胞分化过程中的分子网络。

GSK3β is known to be involved in insulin/IGF signal and canonical Wnt signal, which play important roles in various kinds of biological processes. This study investigated the molecular mechanisms of regulation in bone and metabolism by GSK-3β. We performed the analyses of skeletal phenotype in GSK3β deficient mice under physiological or pathological conditions and functional analyses using mouse primary osteoblasts, chondrocytes, and various cell-lines. We elucidated the molecular network around GSK3β in osteoblast or chondrocyte differentiation.