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Effects of volatile anesthetic(Sevoflurane) on cardiac rhythm and ion channels

Effects of volatile anesthetic(Sevoflurane) on cardiac rhythm and ion channels
挥发性麻醉剂(七氟烷)对心律和离子通道的影响
批准号:
20591796
负责人:
SUZUKI Akihiro
金额:
$2.16万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

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中文摘要
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英文摘要
We electro-physiologically studied the effect of sevoflurane, a volatile anesthesthetic widely used in Japan, on transient outward K (Ito) channel and slow delayed rectifier K (IKs) channel using the patch clamp technique. Sevoflurane suppressed the Ito in a concentration dependent manner. Sevoflurane also suppressed the IKs transfected on HEK cell. Our result indicated that the sevoflurane prolongs action potential by suppressing these potassium channel and may have a similar effect as class III anti-arrythmia drugs.
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作者: []
通讯作者:
吸入麻酔薬が遅延整流Kチャネルに及ぼす影響の調査~タンパク発現マウスHEK細胞を用いて~
研究吸入麻醉剂对延迟整流 K 通道的影响 ~ 使用表达蛋白质的小鼠 HEK 细胞 ~
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Tsuchimochi K, Otero M, Dragomir CL, Plumb DA, Zerbini LF, Libermann TA, Marcu KB, Komiya S, Ijiri K, Goldring MB., 鈴木昭広]
通讯作者: 鈴木昭広
Regulation of root nodule formation by control of light quality and its application for legume production
  • 批准号:
    24658020
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.58万
  • 财政年份:
    2012
  • 负责人:
    SUZUKI Akihiro
  • 依托单位:
development of an economic experiment tool using mobile phone and examination of its effectiveness
  • 批准号:
    23530213
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 资助金额:
    $3.08万
  • 财政年份:
    2011
  • 负责人:
    SUZUKI Akihiro
  • 依托单位:
Analysis of molecular basis for enhanced symbiotic nitrogen fixation and its application for leguminous crops production.
  • 批准号:
    21380016
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 资助金额:
    $10.48万
  • 财政年份:
    2009
  • 负责人:
    SUZUKI Akihiro
  • 依托单位:
Root nodulation is controlled by sensing the R/ FR ratio through phytochrome signaling
  • 批准号:
    21657017
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
  • 资助金额:
    $2.18万
  • 财政年份:
    2009
  • 负责人:
    SUZUKI Akihiro
  • 依托单位:
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