Analysis of cardiac viability after myocardial ischemia and infarction.

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The present study describes a measurement of the dialysate cardiac marker and neurotranmitter levels found in the myocardial interstitial space. Using this cardiac microdialysis technique, myoglobin, as one of the cardiac muscle proteins, release evoked by the desipramine(cell injury-induced drug) was detected as an index of cardiac viability. This index decreased in proportion to the ischemia time. Ischemic preconditioning enhances preservation in cardiac viability. This system offers a new possibility for monitoring cardiac viability after cardiac ischemia/infarction.