Contribution of central norepinephrine to arterial pressure regulation

为了确定中枢去甲肾上腺素对动脉压调节的作用，我们研究了去甲肾上腺素在麻醉家兔延髓背内侧（DM）区的作用。采用透析技术，收集DM区透析液，用高效液相色谱-电化学检测器测定去甲肾上腺素（NE）水平。药物控制性低血压引起透析液NE水平升高。窦主动脉去神经也引起了增加。我们的数据表明，透析液NE水平与动脉压的变化有关。此外，为了确定去甲肾上腺素对动脉压力感受器反射功能的影响，我们注射了α-bolocker，并检查了颈动脉窦压力和肾神经活动之间的开环关系。DM区注射α受体阻滞剂可减弱颈动脉窦压力感受性反射功能。我们的结论是，去甲肾上腺素在DM区的动脉血压调节麻醉兔。

To determine the contribution of central norepinephrine to arterial pressure regulation, we examined the role of norepinephrine at the dorso-medial (DM) region of the medulla oblongata in anesthetized rabbits. Using dialysis technique, we collected dialysates from the DM region and measured norepinephrine (NE) level with a high performance liquid chromatography-electrochemical detector. Drug induced hypotension caused an increase in dialysate NE level. Sino-aortic denervation also elicited an increase. Our data suggested that the dialysate NE level is associated with a change in arterial pressure. Further, to determine the influence of norepinephrine on arterial baroreflex function, we injected an alpha-bolocker and examined the open loop relationship between carotid sinus pressure and renal nerve activity. Carotid sinus baroreflex function was attenuated bu injection of an alpha-blocker into DM region. We conclude that norepinephrine in the DM region contributes to arterial pressure regulation in anethetized rabbits.