Contribution of central norepinephrine to arterial pressure regulation

中枢去甲肾上腺素对动脉压调节的贡献

• 批准号: 02670043
• 负责人: YAMAZAKI Toji
• 金额: $ 1.54万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1990
• 资助国家: 日本
• 起止时间: 1990 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-02670043/
• 关键词: baroreflex; medulla oblongata; central modulation; dialysis; norepinephrine; feed back; baro reflex; 動脈圧反射; マイクロダイアリシス; ノルエピネフリン

To determine the contribution of central norepinephrine to arterial pressure regulation, we examined the role of norepinephrine at the dorso-medial (DM) region of the medulla oblongata in anesthetized rabbits. Using dialysis technique, we collected dialysates from the DM region and measured norepinephrine (NE) level with a high performance liquid chromatography-electrochemical detector. Drug induced hypotension caused an increase in dialysate NE level. Sino-aortic denervation also elicited an increase. Our data suggested that the dialysate NE level is associated with a change in arterial pressure. Further, to determine the influence of norepinephrine on arterial baroreflex function, we injected an alpha-bolocker and examined the open loop relationship between carotid sinus pressure and renal nerve activity. Carotid sinus baroreflex function was attenuated bu injection of an alpha-blocker into DM region. We conclude that norepinephrine in the DM region contributes to arterial pressure regulation in anethetized rabbits.

为了确定中枢去甲肾上腺素对动脉压调节的作用，我们研究了去甲肾上腺素在麻醉家兔延髓背内侧（DM）区的作用。采用透析技术，收集DM区透析液，用高效液相色谱-电化学检测器测定去甲肾上腺素（NE）水平。药物控制性低血压引起透析液NE水平升高。窦主动脉去神经也引起了增加。我们的数据表明，透析液NE水平与动脉压的变化有关。此外，为了确定去甲肾上腺素对动脉压力感受器反射功能的影响，我们注射了α-bolocker，并检查了颈动脉窦压力和肾神经活动之间的开环关系。DM区注射α受体阻滞剂可减弱颈动脉窦压力感受性反射功能。我们的结论是，去甲肾上腺素在DM区的动脉血压调节麻醉兔。

项目成果

山崎 登自: "バソプレッシンと動脈圧反射" 医用電子と生体工学. 30. S45- (1992)

Toji Yamazaki：“加压素和动脉压力反射”医疗电子和生物工程 30. S45- (1992)。

Tsuyoshi Akiyama,Toji Yamazaki,Ishio Ninomiya: "In vivo monitoring of myocardial unterstitial norepinephvine by dialysis technique" AM.J.Physiol. 261. H1643-H1647 (1991)

Tsuyoshi Akiyama、Toji Yamazaki、Ishio Ninomiya：“通过透析技术体内监测心肌间质去甲肾上腺素”AM.J.Physiol。

Toji,Yamazaki,Ishio Ninomiya: "Measurement of dialysate norepinephrine level at the dorso-meeical region of medulla oblongata in anesthetiged rabbits" Jap J Physiol. 41. S74 (1991)

Toji、Yamazaki、Ishio Ninomiya：“麻醉兔子延髓背侧-meeical 区域透析液去甲肾上腺素水平的测量”Jap J Physiol。

Tsuyoshi.AKIYAMA,: "In vivo monitoring of myocardial interstitial norepinephrine by dialysis technique." Am.J.Physiol.261. H1643-1647 (1991)

Tsuyoshi.AKIYAMA，：“通过透析技术体内监测心肌间质去甲肾上腺素。”

Tsuyoshi Akiyama: "In vivo monitoring of myocardial interstitial norepinephrine by dialysis technique" Am. J. Physiol. Vol.261. H1643-1647 (1991)

Tsuyoshi Akiyama：“通过透析技术体内监测心肌间质去甲肾上腺素”Am。