Development of novel gene therapy for hormone refractory prostate cancer

开发激素难治性前列腺癌的新型基因疗法

• 批准号: 20591868
• 负责人: KIYOTA Hiroshi
• 金额: $ 3万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2008
• 资助国家: 日本
• 起止时间: 2008 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-20591868/
• 关键词: 癌; 泌尿器科; 前立腺癌; 遺伝子治療

The aim of this study is to develop the new gene therapy using lentiviral vector with prostate-specific promoter that induces therapeutic gene to prostate cancer specifically. Lentiviral vectors with prostate-specific promoters were constructed and the efficiency was observed in vitro and in vivo models.

本研究的目的是利用携带前列腺特异性启动子的慢病毒载体，特异性地诱导治疗性基因治疗前列腺癌。构建前列腺特异性启动子慢病毒载体，并在体外和体内模型中观察其效率。