The role of apoptosis in growth and survival of endometriotic cells : its implication for treatment of endometrisois
The role of apoptosis in growth and survival of endometriotic cells : its implication for treatment of endometrisois
批准号:
20591915
负责人:
HARADA Tasuku
金额:
$2.91万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
点击翻译按钮获取中文摘要
英文摘要
Decreased susceptibility of endometrial tissue to apoptosis may contribute to the pathogenesis of endometriosis. Endometriotic stromal cells showed resistance to drug-induced apoptosis compared with eutopic endometrial cells. Survivin gene and protein expression was enhanced in endometriotic cells and tissues. Survivin may play a critical role in susceptibility of endometriosis to apoptosis. The data also suggest that survivin inhibitor may be effective as a therapeutic agent for endometriosis.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
子宮内膜症細胞のサイトカイン産生に対するIL-10の影響と細胞内シグナル伝達
IL-10对子宫内膜异位症细胞细胞因子产生和细胞内信号转导的影响
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[田頭由紀子、谷口文紀、原田省、寺川直樹, 他]
通讯作者:
他
Lipopolysaccharide promoted roliferation and invasion of endometriotic stromal cells via induction of cyclooxygenase-2 expression.
脂多糖通过诱导环氧合酶2表达促进子宫内膜异位基质细胞的增殖和侵袭。
DOI:
--
发表时间:
2010
期刊:
Fertil.Steril. 93(1)
影响因子:
--
作者:
[Takenaka Y, Taniguchi F, Miyakoda H, Takai E, Terakawa N, Harada T]
通讯作者:
Harada T
パスウェイ特異的アレイを用いた子宮内膜症細胞のアポトーシス抵抗性の解明
使用途径特异性阵列阐明子宫内膜异位症细胞的凋亡抗性
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[谷口文紀, 池田綾子, 渡邉彩子, 田頭由紀子, 周防加奈, 岩部富夫, 原田省, 寺川直樹]
通讯作者:
寺川直樹
Apigeninによる子宮内膜症間質細胞の増殖およびPGE2産生の抑制
芹菜素抑制子宫内膜异位基质细胞增殖和 PGE2 产生
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[周防加奈、谷口文紀、原田省寺川直樹, 他]
通讯作者:
他
DOI:
10.1016/j.fertnstert.2007.08.051
发表时间:
2008-11-01
期刊:
FERTILITY AND STERILITY
影响因子:
6.7
作者:
[Harada, Tastuku, Monzoeda, Mikio, Terakawa, Naoki]
通讯作者:
Terakawa, Naoki
共 35 条
Development of a New Selective Estrogen Receptor Modulator for the Treatment of Endometriosis
-
批准号:18K09290
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.91万
-
财政年份:2018
-
负责人:HARADA Tasuku
-
依托单位:
Molecular basis of novel estrogen receptor variants expressed in endometriotic tissues
-
批准号:24659731
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.16万
-
财政年份:2012
-
负责人:HARADA Tasuku
-
依托单位:
Development of anti-cytokine drugs for treatment of endometriosis
-
批准号:13671715
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.56万
-
财政年份:2001
-
负责人:HARADA Tasuku
-
依托单位:
Role of cytokines in development of endometriosis
-
批准号:10671540
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.11万
-
财政年份:1998
-
负责人:HARADA Tasuku
-
依托单位:
Coculture of preimplantation embryo with an immortalized human oviductal epithelial cells
-
批准号:06671654
-
项目类别:Grant-in-Aid for General Scientific Research (C)
-
资助金额:$1.09万
-
财政年份:1994
-
负责人:HARADA Tasuku
-
依托单位:
海外基金