Development of anti-tumor gene therapy for retinoblastoma using Sendai virus vector and IFNB gene.
Development of anti-tumor gene therapy for retinoblastoma using Sendai virus vector and IFNB gene.
批准号:
20592047
负责人:
YOSHIKAWA Hiroshi
金额:
$3.0万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
我们研究了M基因缺陷仙台病毒载体编码IFN-β基因(SeV/ΔM-IFN-β)的抗肿瘤基因治疗是否具有治疗视网膜母细胞瘤的潜力。虽然SeV/ΔM载体在视网膜母细胞瘤细胞系中的基因转导效率较低,但它在视网膜色素上皮(RPE)来源的细胞系中介导了高效的基因转移。SeV/ΔM-mediated在RPE中过表达IFN-β抑制了视网膜母细胞瘤细胞的生长,提示使用SeV/ΔM载体眼内转移IFN-β基因可能是阻止视网膜母细胞瘤患者肿瘤生长的有效策略。
英文摘要
We investigated weather anti-tumor gene therapy using M gene deficient Sendai virus vector encoding IFN-β gene (SeV/ΔM-IFN-β) has therapeutic potentials for the treatment of retinoblastoma. Whereas the gene transduction efficiency of SeV/ΔM vector is low in retinoblastoma cell lines, it mediates efficient gene transfer in a retinal pigment epithelium (RPE)-derived cell line. SeV/ΔM-mediated overexpression of IFN-β in RPE suppressed the growth of retinoblastoma cells, suggesting that intraocular IFN-β gene transfer using SeV/ΔM vector may be a useful strategy for preventing tumor growth in retinoblastoma patients.
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Pedagogical Effects of Outer Circle Englishes on Japanese Learners of English
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Pedagogical effects of World Englishes on Japanese English learners
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International Intelligibility of Japanese English - from the Viewpoints of World Englishes and Cross-cultural Understanding
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Mechanism of Initiation of Replication of the Chromosome VI of Saccharomyces cerevisiae
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Control of chromosomal replication in relation to cell duplication
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