Implication of the endoplasmic reticulum stress response in postischemic alopecia and tolerance for ischemic stress of hair follicles.

本研究旨在揭示皮瓣短暂缺血后脱发的发生机制。皮瓣缺血应激时，生长期毛囊进入皮下组织与静止期毛囊停留在真皮组织对缺血应激的耐受性不同。这表明，短暂缺血应激与生长期毛囊选择性地引起脱发。提示内质网应激反应是导致生长期和休止期卵泡耐受性差异的因素之一。

The purpose of this study is to reveal the mechanism of alopecia after transient ischemia in the skin flaps. Under ischemic stress with skin flaps, the tolerance for ischemic stress was difference between anagen follicles which got into subcutaneous tissue and telogen follicles which staid in dermis tissue. This made it clear that transient ischemic stress with anagen follicles caused alopecia selectively. And this study suggest that one of a factor made these differences of tolerance with anagen and telogen follicles was the endoplasmic reticulum stress response.