Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: a critical role of endothelial nitric oxide synthase.

低能量体外冲击波疗法可增强糖尿病小鼠的皮肤伤口愈合：内皮一氧化氮合酶的关键作用。

• 批准号: 23592639
• 负责人: IMAI Yoshimichi
• 金额: $ 3.41万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2013
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23592639/
• 关键词: 体外衝撃波治療; 慢性創傷; 血管新生; 創傷治癒; 対外衝撃波治療

There is the country where low power outside the body shock wave treatment is really used for for a diabetic foot ulcer and a chronic leg ulcer in the Western European countries, but the authorization in this country is not done. The fundamental law can expect the role as the ace in the hole in the case that revascularizing it has difficult for diabetes, the arterial ischemia-related ulcer caused by the seriously ill ischemic limb (occlusive arteriosclerosis). The vascularization action was clarified through animal experiment. I pushed forward preparations for clinical application in parallel.

在西欧国家，低功率体外冲击波治疗确实用于糖尿病足溃疡和慢性腿部溃疡，但该国尚未获得授权。本法对于糖尿病、重症缺血性肢体（闭塞性动脉硬化）引起的动脉缺血性溃疡，在血运重建困难的情况下可期待作为王牌的作用。通过动物实验阐明其血管化作用。我同时推进了临床应用的准备工作。

项目成果

Low-energy extracorporeal shock wave therapy enhances skin wound healing in diabetic mice: A critical role of endothelial nitric oxide synthase

• DOI: 10.1111/j.1524-475x.2012.00851.x
• 发表时间: 2012-11-01
• 期刊: WOUND REPAIR AND REGENERATION
• 影响因子: 2.9
• 作者: Hayashi, Denso;Kawakami, Kazuyoshi;Tachi, Masahiro
• 通讯作者: Tachi, Masahiro

STZ誘発糖尿病モデル慢性皮膚潰瘍に対する低出力体外衝撃波治療の有効性の検討について

低功率体外冲击波治疗 STZ 诱导的糖尿病模型中慢性皮肤溃疡的有效性研究

• 发表时间: 2012
• 作者: Shibuya N;Imai Y;Lee YS;Kochi T;Tachi M;林殿聡,川上和義,伊藤健太,下川宏明,館正弘
• 通讯作者: 林殿聡,川上和義,伊藤健太,下川宏明,館正弘