Treatment of infected wound with omentum-derived cells

肌瓣和网膜瓣用于治疗感染伤口。根据我们的临床经验和以往的实验，我们认为大网膜瓣比肌瓣更能有效地治疗感染创面。然而，有关网膜瓣抗感染的报道较少。在我们建立了一个新的感染伤口模型后，我们比较了网膜瓣和肌瓣在这个模型中的作用。此外，我们研究了网膜来源的细胞的抗感染作用。首先，我们采用半流体培养基加金黄色葡萄球菌建立了一种新的稳定的感染创面模型。当我们在这个模型中比较网膜瓣和肌瓣时，一些肌瓣对感染的伤口有反应。另一方面，大网膜瓣对伤口有反应：大网膜瓣与周围组织粘附，并提供大量炎性细胞。当我们将网膜来源的细胞注射到感染的伤口时，这些细胞局部存活并伴有新生血管形成，并且被大量炎性细胞包围。总的来说，这些发现表明网膜瓣比肌瓣更有效地治疗感染伤口。网膜细胞有可能对感染的伤口有抗感染作用。

Muscle flaps and omental flaps are used for treatment of infected wound. We think omental flaps are more effective for infected wound than muscle flaps by our clinical experiences and previous experiments. However, there are few repots involving anti-infective effects of omental flaps. After we established a new infected wound model, we compared omental flaps to muscle flaps in this model. Furthermore, we investigated the anti-infective effects of omentum-derived cells. At first, we established a new stable infected wound model by the semi-fluid medium plus Staphylococcus aureus. When we compared omental flaps to muscle flaps in this model, a few muscle flaps responded to the infected wound. On the other hand, most omental flaps responded to the wound : omental flaps adhered the surrounding tissue and supplied a lot of inflammatory cells. When we injected the omentum-derived cells to the infected wound, these cells survived locally with neovascularization and were surrounded by a lot of inflammatory cells. Taken together, these findings indicate omental flaps are more effective for infected wound than muscle flap. There's a possibility that omentum-derived cells have the anti-infective effect for the infected wound.