Roles of cytoskeletal proteins in organic fibrosis and their application of therapy in fibrotic diseases

当transgelin的表达被敲低时，肌成纤维细胞的激活被抑制。TGF-β刺激人肺成纤维细胞后，整合素α11 （ITGA11）表达明显升高。钙与整合素结合蛋白1 （CIB1）结合到ITGA11的胞内结构域。TGF-β处理的人肺成纤维细胞和博莱霉素处理的小鼠肺组织中CIB1的表达增加。这些结果提示CIB1可能参与了纤维化。

Activation of myofibroblasts was inhibited when the expression of transgelin was knocked down. When human lung fibroblasts were stimulated by TGF-β, the integrin α11 (ITGA11) expression was markedly increased. Calcium and integrin binding protein 1 (CIB1) bound to the intracellular domain of ITGA11. The expression of CIB1 increased in human lung fibroblasts treated with TGF-β and in bleomycin-treated mice pulmonary tissues. These results suggest that CIB1 may be involved in the fibrosis.